A nanofibrous sheet-based system for linear delivery of nifedipine

We developed a nanofibrous sheet-based system to achieve linear release of nifedipine for oral delivery. The nanofibrous sheets of micro-porosity were fabricated by the electrospinning method, using a biocompatible polymer, poly (lactic-co-glycolic acid). The sheets were then used as a drug diffusion barrier by capping and sealing a compressed tablet, composed of nifedipine and a solubility enhancer, polyvinylpyrrolidone. The nanofibrous sheets of different thicknesses were prepared to vary the rate of drug diffusion in this work. In vitro drug release study revealed that as the sheet thickness increased, drug release was more retarded, where a lag phase of drug release became more evident. We were to realize linear drug release by combining two distinctly capped tablets, each showing a different drug release, which exhibited an almost linear release of nifedipine during 24 h (R-2 > 0.986). The drug release profile was not influenced by the pH of the release media as the morphological structure of nanofibrous sheets was seen to be not very different at both pHs 1.2 and 6.8. Therefore, we conclude that a combination of two tablets, each capped with nanofibrous sheets of different thickness, is a promising system for linear delivery of oral drug. (C) 2010 Elsevier B.V. All rights reserved.