Triterpenoids with α-glucosidase inhibitory activity from Artemisia argyi

被引：28
作者：
Zhang, Lai-Bin [1 ]
Chang, Jia-Jing [1 ]
Guo, Li-Min [1 ]
Lv, Jie-Li [1 ]
机构：
[1] Xinxiang Med Univ, Sch Pharm, 601 Jin Sui Rd, Xinxiang 453003, Henan, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Artemisia argyi; compositae; triterpenoids; alpha-glucosidase inhibitory activity; HIGH-FAT DIET; CONSTITUENTS;
D O I：
10.1080/10286020.2018.1543281
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new nordammarane-type triterpenoids, 3 beta-acetoxy-20-oxo-21-nordammaran-23-carboxylic acid methyl ester (1) and 3 beta-acetoxy-17 beta-dammaranic acid (2), along with two known cycloartane-type triterpenoids (3-4), were isolated from the petroleum ether-soluble extract of Artemisia argyi. Their structures were elucidated based on 1D and 2D NMR spectroscopic data analysis. All compounds were evaluated for their alpha-glucosidase inhibitory activity in vitro. Compounds 1-4 exhibited significant inhibitory effects on alpha-glucosidase with IC50 values ranging from 38.34 +/- 0.23 to 105.54 +/- 0.33 mu M.
引用
收藏
页码：241 / 248
页数：8
相关论文
共 25 条
  • [1] α-glucosidase inhibitory activity of triterpenoids from Cichorium intybus
    Atta-Ur-Rahman
    Zareen, Seema
    Choudhary, M. Iqbal
    Akhtar, M. Nadeern
    Khan, Shamsun Nahar
    [J]. JOURNAL OF NATURAL PRODUCTS, 2008, 71 (05): : 910 - 913
  • [2] Antitumor and immunomodulatory activities of a polysaccharide from Artemisia argyi
    Bao, Xiaoli
    Yuan, Huihui
    Wang, Chengzhong
    Liu, Jinjin
    Lan, Minbo
    [J]. CARBOHYDRATE POLYMERS, 2013, 98 (01) : 1236 - 1243
  • [3] Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase
    Chen, Xian-Qiang
    Zhao, Jing
    Chen, Ling-Xiao
    Wang, Shen-Fei
    Wang, Ying
    Li, Shao-Ping
    [J]. PHYTOCHEMISTRY, 2018, 149 : 103 - 115
  • [4] Triterpenoid-Rich Fraction from Ilex hainanensis Merr. Attenuates Non-Alcoholic Fatty Liver Disease Induced by High Fat Diet in Rats
    Cui, Wei-Xi
    Yang, Jie
    Chen, Xiao-Qing
    Mao, Qian
    Wei, Xiang-Lan
    Wen, Xiao-Dong
    Wang, Qiang
    [J]. AMERICAN JOURNAL OF CHINESE MEDICINE, 2013, 41 (03): : 487 - 502
  • [5] CYCLOARTANE TRITERPENES FROM JUNCUS-EFFUSUS
    DELLAGRECA, M
    FIORENTINO, A
    MONACO, P
    PREVITERA, L
    [J]. PHYTOCHEMISTRY, 1994, 35 (04) : 1017 - 1022
  • [6] Functional significance and structure-activity relationship of food-derived α-glucosidase inhibitors
    Di Stefano, Elisa
    Oliviero, Teresa
    Udenigwe, Chibuike C.
    [J]. CURRENT OPINION IN FOOD SCIENCE, 2018, 20 : 7 - 12
  • [7] Novel oxazolxanthone derivatives as a new type of α-glucosidase inhibitor: synthesis, activities, inhibitory modes and synergetic effect
    Ding, Sen-Miao
    Lan, Tian
    Ye, Gao-Jie
    Huang, Jia-Jun
    Hu, You
    Zhu, Yi-Ran
    Wang, Bo
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (12) : 3370 - 3378
  • [8] Constituents from the testas of Castanea mollissima Blume with α-glucosidase inhibitory activity
    Gao, Hui-Yuan
    Wu, Di
    Lu, Chuan
    Xu, Xiao-Min
    Huang, Jian
    Sun, Bo-Hang
    Wu, Li-Jun
    [J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2010, 12 (02) : 144 - 149
  • [9] The aerial parts of Salvia miltiorrhiza Bge. strengthen intestinal barrier and modulate gut microbiota imbalance in streptozocin-induced diabetic mice
    Gu, Jun-Fei
    Su, Shu-Lan
    Guo, Jian-Ming
    Zhu, Yue
    Zhao, Ming
    Duan, Jin-Ao
    [J]. JOURNAL OF FUNCTIONAL FOODS, 2017, 36 : 362 - 374
  • [10] Anti-Inflammatory Oleanolic Triterpenes from Chinese Acorns
    Huang, Jie
    Wang, Yihai
    Li, Chuan
    Wang, Xinluan
    He, Xiangjiu
    [J]. MOLECULES, 2016, 21 (05):
123