Vaccine design and delivery approaches for COVID-19

被引:21
作者
Shahzamani, Kiana [1 ]
Mahmoudian, Fatemeh [2 ]
Ahangarzadeh, Shahrzad [3 ]
Ranjbar, Mohammad Mehdi [4 ]
Beikmohammadi, Leila [5 ,6 ]
Bahrami, Samira [7 ]
Mohammadi, Elmira [8 ,9 ]
Esfandyari, Sahar [10 ]
Alibakhshi, Abbas [11 ]
Javanmard, Shaghayegh Haghjooy [8 ]
机构
[1] Isfahan Univ Med Sci, Isfahan Gastroenterol & Hepatol Res Ctr IGHRC, Esfahan, Iran
[2] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Mol Med, Tehran, Iran
[3] Isfahan Univ Med Sci, Infect Dis & Trop Med Res Ctr, Esfahan, Iran
[4] Agr Res Educ & Extens Org AREEO, Razi Vaccine & Serum Res Inst, Karaj, Iran
[5] Erasmus MC, Dept Biochem, Rotterdam, Netherlands
[6] Univ Tehran Med Sci, Stem Cell & Regenerat Med Ctr Excellence, Tehran 141556559, Iran
[7] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Biotechnol Dept, Tehran, Iran
[8] Isfahan Univ Med Sci, Appl Physiol Res Ctr, Cardiovasc Res Inst, Dept Physiol, Esfahan, Iran
[9] Isfahan Univ Med Sci, Core Res Facil, Esfahan, Iran
[10] Univ Tehran Med Sci, Sch Med, Dept Anat, Tehran, Iran
[11] Hamadan Univ Med Sci, Mol Med Res Ctr, Hamadan, Hamadan, Iran
关键词
COVID-19; SARS-CoV-2; Vaccine; Vaccine design; Vaccine delivery; RECEPTOR-BINDING DOMAIN; SARS; SARS-COV-2; PROTEIN; VIRUS; IMMUNOGENICITY; STRATEGIES; MUTATIONS; SYSTEM; COV;
D O I
10.1016/j.intimp.2021.108086
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
COVID-19 is still a deadly disease that remains yet a major challenge for humans. In recent times, many large pharmaceutical and non-pharmaceutical companies have invested a lot of time and cost in fighting this disease. In this regard, today's scientific knowledge shows that designing and producing an effective vaccine is the best possible way to diminish the disease burden and dissemination or even eradicate the disease. Due to the urgent need, many vaccines are now available earlier than scheduled. New technologies have also helped to produce much more effective vaccines, although the potential side effects must be taken into account. Thus, in this review, the types of vaccines and vaccine designs made against COVID-19, the vaccination programs, as well as the delivery methods and molecules that have been used to deliver some vaccines that need a carrier will be described.
引用
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页数:13
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