Gastric adenocarcinoma of the fundic gland: A review of clinicopathological characteristics, treatment and prognosis

被引：11

作者：

Meng, Xiang-yu ^{[2
]}

Yang, Guang ^{[1
,3
]}

Dong, Cheng-ji ^{[4
]}

Zheng, Ru-yi ^{[5
]}

机构：

[1] Okayama Univ, Dept Pathol Dent & Pharmaceut Sci, Grad Sch Med, Okayama, Japan

[2] Mudanjiang Med Univ, Dept Biochem & Mol Biol, Mudanjiang, Peoples R China

[3] Mudanjiang Med Univ, Dept Pathol, Mudanjiang, Peoples R China

[4] First Hosp Jilin Univ, Dept Hepatobiliary & Pancreas Surg, Changchun, Peoples R China

[5] Mine Hosp Xu Zhou, Med Imaging Ctr, Xuzhou, Jiangsu, Peoples R China

来源：

RARE TUMORS | 2021年 / 13卷

关键词：

Gastric adenocarcinoma of the fundic gland; chief cells; histopathology; treatment; prognosis; CATENIN SIGNALING PATHWAY; CELL PREDOMINANT TYPE; HELICOBACTER-PYLORI; NEOPLASIA; MUTATION; FEATURES; PROPOSAL;

D O I：

10.1177/20363613211060171

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric adenocarcinoma of the fundic gland is a rare, well-differentiated gastric cancer entity, and very few patients transition to poorly differentiated tubular adenocarcinoma during progression. Gastric adenocarcinoma of the fundic gland originates from the mucosa of the gastric fundic gland, usually without chronic gastritis or intestinal metaplasia. Histologically, the tumor cells are closely arranged to form anastomosing tubular glands, and more than 95% of tumor cells differentiate towards chief cells. Most gastric adenocarcinoma of the fundic gland cases are characterized by submucosal involvement, but the tumor volume is usually small, with lymphatic and vascular invasion rarely observed. Therefore, endoscopic submucosal dissection can be an ideal treatment, leading to a favorable prognosis, and recurrence and metastasis of the disease are uncommon.

引用

页数：7

共 44 条

[1] Helicobacter pylori and nutrition: a bidirectional communication [J].

Aimasso, Umberto ;

D'Onofrio, Valentina ;

D'Eusebio, Chiara ;

Devecchi, Andrea ;

Pira, Costanza ;

Merlo, Fabio D. ;

De Francesco, Antonella .

MINERVA GASTROENTEROLOGICA E DIETOLOGICA, 2019, 65 (02) :116-129

[2] Comprehensive molecular characterization of gastric adenocarcinoma [J].

Bass, Adam J. ;

Thorsson, Vesteinn ;

Shmulevich, Ilya ;

Reynolds, Sheila M. ;

Miller, Michael ;

Bernard, Brady ;

Hinoue, Toshinori ;

Laird, Peter W. ;

Curtis, Christina ;

Shen, Hui ;

Weisenberger, Daniel J. ;

Schultz, Nikolaus ;

Shen, Ronglai ;

Weinhold, Nils ;

Keiser, David P. ;

Bowlby, Reanne ;

Sipahimalani, Payal ;

Cherniack, Andrew D. ;

Getz, Gad ;

Liu, Yingchun ;

Noble, Michael S. ;

Pedamallu, Chandra ;

Sougnez, Carrie ;

Taylor-Weiner, Amaro ;

Akbani, Rehan ;

Lee, Ju-Seog ;

Liu, Wenbin ;

Mills, Gordon B. ;

Yang, Da ;

Zhang, Wei ;

Pantazi, Angeliki ;

Parfenov, Michael ;

Gulley, Margaret ;

Piazuelo, M. Blanca ;

Schneider, Barbara G. ;

Kim, Jihun ;

Boussioutas, Alex ;

Sheth, Margi ;

Demchok, John A. ;

Rabkin, Charles S. ;

Willis, Joseph E. ;

Ng, Sam ;

Garman, Katherine ;

Beer, David G. ;

Pennathur, Arjun ;

Raphael, Benjamin J. ;

Wu, Hsin-Ta ;

Odze, Robert ;

Kim, Hark K. ;

Bowen, Jay .

NATURE, 2014, 513 (7517) :202-209

[3]

Benedict MA, 2018, AM J CLIN PATHOL, V149, P461, DOI [10.1093/AJCP/AQY019, 10.1093/ajcp/aqy019]

[4]

Cha Hee Jeong, 2016, Case Rep Gastroenterol, V10, P292, DOI 10.1159/000444277

[5] Multiple gastric adenocarcinoma of fundic gland type: A case report [J].

Chen, Ou ;

Shao, Ze-Yong ;

Qiu, Xiong ;

Zhang, Guang-Ping .

WORLD JOURNAL OF CLINICAL CASES, 2019, 7 (18) :2871-2878

[6] Clinicopathological features of gastric adenocarcinoma of the fundic gland (chief cell predominant type) by retrospective and prospective analyses of endoscopic findings [J].

Chiba, Takashi ;

Kato, Katsuaki ;

Masuda, Takayuki ;

Ohara, Shuichi ;

Iwama, Noriyuki ;

Shimada, Takenobu ;

Shibuya, Daisuke .

DIGESTIVE ENDOSCOPY, 2016, 28 (07) :722-730

[7] Chronic gastritis according to age and Helicobacter pylori in Thailand: histopathological patterns [J].

Chitapanarux, Taned ;

Jesadaporn, Panas ;

Chitapanarux, Nalin ;

Lertprasertsuke, Nirush .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2021, 56 (03) :228-233

[8] Gastric adenocarcinoma of the fundic gland type A case report [J].

Fan, Xue ;

Yang, Xue-Song ;

Bai, Peng ;

Ren, Yu-Bo ;

Zhang, Lei ;

Li, Xin ;

Wang, Li ;

Wang, Yan ;

Ding, Yi-Ming ;

Zeng, Ran-Ran ;

Lin, Xiang-Chun .

MEDICINE, 2020, 99 (21) :E20361

[9] GASTRIC ADENOCARCINOMA OF FUNDIC GLAND TYPE (CHIEF CELL PREDOMINANT TYPE) TREATED WITH ENDOSCOPIC ASPIRATION MUCOSECTOMY [J].

Fukatsu, Hirotoshi ;

Miyoshi, Haruka ;

Ishiki, Kuniharu ;

Tamura, Maiko ;

Yao, Takashi .

DIGESTIVE ENDOSCOPY, 2011, 23 (03) :244-246

[10] Alteration in the Wnt/β-catenin signaling pathway in gastric neoplasias of fundic gland (chief cell predominant) type [J].

Hidaka, Yasuhiro ;

Mitomi, Hiroyuki ;

Saito, Tsuyoshi ;

Takahashi, Michiko ;

Lee, Se-yong ;

Matsumoto, Kenshi ;

Yao, Takashi ;

Watanabe, Sumio .

HUMAN PATHOLOGY, 2013, 44 (11) :2438-2448

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