Temporal Subtraction of Serial CT Images with Large Deformation Diffeomorphic Metric Mapping in the Identification of Bone Metastases

被引：32

作者：

Sakamoto, Ryo ^{[1
]}

Yakami, Masahiro ^{[1
]}

Fujimoto, Koji ^{[1
]}

Nakagomi, Keita ^{[2
,3
]}

Kubo, Takeshi ^{[1
]}

Emoto, Yutaka ^{[4
]}

Akasaka, Thai ^{[1
]}

Aoyama, Gakuto ^{[2
,3
]}

Yamamoto, Hiroyuki ^{[2
,3
]}

Miller, Michael I. ^{[5
,6
]}

Mori, Susumu ^{[7
,8
]}

Togashi, Kaori ^{[1
]}

机构：

[1] Kyoto Univ, Dept Diagnost Imaging & Nucl Med, Grad Sch Med, Sakyo Ku, 54 Kawaharacho, Kyoto 6068507, Japan

[2] Canon, Adv Informat & Real World Technol Dev Ctr 1, Kyoto, Japan

[3] Kyoto Univ Hosp, Clin Res Ctr Med Equipment Dev, Sakyo Ku, Kyoto, Japan

[4] Kyoto Coll Med Sci, Dept Med Sci, Kyoto, Japan

[5] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA

[6] Johns Hopkins Univ, Ctr Imaging Sci, Baltimore, MD USA

[7] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Sch Med, Baltimore, MD USA

[8] Johns Hopkins Univ, Kennedy Krieger Inst, FM Kirby Funct Imaging Ctr, Baltimore, MD USA

来源：

RADIOLOGY | 2017年 / 285卷 / 02期

关键词：

COMPUTER-AIDED DETECTION; THORACOLUMBAR SPINE; INTERVAL CHANGES; BREAST-CANCER; LUNG-CANCER; FDG-PET/CT; PERFORMANCE; TOMOGRAPHY; OBSERVER; LESIONS;

D O I：

10.1148/radiol.2017161942

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To determine the improvement of radiologist efficiency and performance in the detection of bone metastases at serial follow-up computed tomography (CT) by using a temporal subtraction (TS) technique based on an advanced nonrigid image registration algorithm. Materials and Methods: This retrospective study was approved by the institutional review board, and informed consent was waived. CT image pairs (previous and current scans of the torso) in 60 patients with cancer (primary lesion location: prostate, n = 14; breast, n = 16; lung, n = 20; liver, n = 10) were included. These consisted of 30 positive cases with a total of 65 bone metastases depicted only on current images and confirmed by two radiologists who had access to additional imaging examinations and clinical courses and 30 matched negative control cases (no bone metastases). Previous CT images were semiautomatically registered to current CT images by the algorithm, and TS images were created. Seven radiologists independently interpreted CT image pairs to identify newly developed bone metastases without and with TS images with an interval of at least 30 days. Jackknife free-response receiver operating characteristics (JAFROC) analysis was conducted to assess observer performance. Reading time was recorded, and usefulness was evaluated with subjective scores of 1-5, with 5 being extremely useful and 1 being useless. Significance of these values was tested with the Wilcoxon signed-rank test. Results: The subtraction images depicted various types of bone metastases (osteolytic, n = 28; osteoblastic, n = 26; mixed osteolytic and blastic, n = 11) as temporal changes. The average reading time was significantly reduced (384.3 vs 286.8 seconds; Wilcoxon signed rank test, P = .028). The average figure-of-merit value increased from 0.758 to 0.835; however, this difference was not significant (JAFROC analysis, P = .092). The subjective usefulness survey response showed a median score of 5 for use of the technique (range, 3-5). Conclusion: TS images obtained from serial CT scans using nonrigid registration successfully depicted newly developed bone metastases and showed promise for their efficient detection. (C) RSNA, 2017

引用

页码：629 / 639

页数：11

共 23 条

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