A 2022 Systematic Review and Meta-Analysis of Enriched Therapeutic Diets and Nutraceuticals in Canine and Feline Osteoarthritis

被引：30

作者：

Barbeau-Gregoire, Maude ^{[1
]}

Otis, Colombe ^{[1
]}

Cournoyer, Antoine ^{[1
]}

Moreau, Maxim ^{[1
]}

Lussier, Bertrand ^{[1
,2
]}

Troncy, Eric ^{[1
,2
]}

机构：

[1] Univ Montreal, Fac Med Vet, Dept Biomed Vet, Grp Rech Pharmacol Anim Quebec GREPAQ, St Hyacinthe, PQ J2S 7C6, Canada

[2] Ctr Rech Ctr Hosp Univ LUniv Montreal, Unite Rech Arthrose, Montreal, PQ H2X 0A9, Canada

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 18期

基金：

加拿大自然科学与工程研究理事会;

关键词：

osteoarthritis; nutraceuticals; enriched diets; pain; animal; methodological quality; scientific evidence; metrological validation; GREEN-LIPPED MUSSEL; COLLAGEN UC-II; FISH-OIL OMEGA-3-FATTY-ACIDS; DOUBLE-BLIND; CHONDROITIN SULFATE; CLINICAL SIGNS; GENE-EXPRESSION; WEIGHT-BEARING; DOGS; GLUCOSAMINE;

D O I：

10.3390/ijms231810384

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With osteoarthritis being the most common degenerative disease in pet animals, a very broad panel of natural health products is available on the market for its management. The aim of this systematic review and meta-analysis, registered on PROSPERO (CRD42021279368), was to test for the evidence of clinical analgesia efficacy of fortified foods and nutraceuticals administered in dogs and cats affected by osteoarthritis. In four electronic bibliographic databases, 1578 publications were retrieved plus 20 additional publications from internal sources. Fifty-seven articles were included, comprising 72 trials divided into nine different categories of natural health compound. The efficacy assessment, associated to the level of quality of each trial, presented an evident clinical analgesic efficacy for omega-3-enriched diets, omega-3 supplements and cannabidiol (to a lesser degree). Our analyses showed a weak efficacy of collagen and a very marked non-effect of chondroitin-glucosamine nutraceuticals, which leads us to recommend that the latter products should no longer be recommended for pain management in canine and feline osteoarthritis.

引用

页数：23

共 135 条

[1] The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs [J].