Inflammatory Targets in Diabetic Nephropathy

被引:165
作者
Donate-Correa, Javier [1 ,2 ]
Luis-Rodriguez, Desiree [3 ]
Martin-Nunez, Ernesto [1 ,2 ,4 ]
Tagua, Victor G. [1 ]
Hernandez-Carballo, Carolina [5 ]
Ferri, Carla [1 ,4 ]
Elena Rodriguez-Rodriguez, Ana [6 ]
Mora-Fernandez, Carmen [1 ,2 ,7 ]
Navarro-Gonzalez, Juan F. [1 ,2 ,3 ,7 ,8 ]
机构
[1] Hosp Univ Nuestra Senora Candelaria, Unidad Invest, Santa Cruz De Tenerife 38010, Spain
[2] GEENDIAB Grp Espanol Estudio Nefropatia Diabet, Sociedad Espanola Nefrol, Santander 39008, Spain
[3] Hosp Univ Nuestra Senora Candelaria, Serv Nefrol, Santa Cruz De Tenerife 38010, Spain
[4] Univ La Laguna, Escuela Doctorado & Estudios Posgrad, San Cristobal De Laguna 38200, Spain
[5] Hosp Nuestra Senora Candelaria, Serv Med Interna, Santa Cruz De Tenerife 38010, Spain
[6] Hosp Univ Canarias, Unidad Invest, San Cristobal De Laguna 38008, Spain
[7] Inst Salud Carlos III, REDINREN Red Invest Renal RD16 0009 0022, Madrid 28029, Spain
[8] Univ La Laguna, Inst Tecnol Biomed, San Cristobal De Laguna 38010, Spain
关键词
renal disease; diabetes; inflammation; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; MONOCYTE CHEMOATTRACTANT PROTEIN-1; C-REACTIVE PROTEIN; CONVERTING ENZYME-INHIBITION; GLUCOSE COTRANSPORTER 2; ISOLATED RAT GLOMERULI; INNATE IMMUNE-SYSTEM; ANGIOTENSIN-II; FACTOR-ALPHA;
D O I
10.3390/jcm9020458
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
One of the most frequent complications in patients with diabetes mellitus is diabetic nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and the main cause of cardiovascular morbidity and mortality in these patients. Therefore, it is clear that new strategies are required to delay the development and the progression of this pathology. This new approach should look beyond the control of traditional risk factors such as hyperglycemia and hypertension. Currently, inflammation has been recognized as one of the underlying processes involved in the development and progression of kidney disease in the diabetic population. Understanding the cascade of signals and mechanisms that trigger this maladaptive immune response, which eventually leads to the development of DN, is crucial. This knowledge will allow the identification of new targets and facilitate the design of innovative therapeutic strategies. In this review, we focus on the pathogenesis of proinflammatory molecules and mechanisms related to the development and progression of DN, and discuss the potential utility of new strategies based on agents that target inflammation.
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页数:23
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