Two New Chromone Derivatives from Cassia nomame and their Anti-Tobacco Mosaic Virus Activity

被引：6

作者：

Liao, Ling-Min ^{[1
,2
]}

Sun, Yan-Qi ^{[1
,2
]}

Li, Jing ^{[2
]}

Kong, Wei-Song ^{[2
]}

Liu, Xin ^{[2
]}

Xu, Yong ^{[2
]}

Huang, Hai-Tao ^{[2
]}

Zeng, Wan-Li ^{[2
]}

Mi, Qi-Li ^{[2
]}

Yang, Guang-Yu ^{[1
,2
]}

Hu, Qiu-Fen ^{[1
]}

Li, Yin-Ke ^{[1
,2
]}

机构：

[1] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, Kunming 650031, Yunnan, Peoples R China

[2] China Tobacco Yunnan Ind Co Ltd, Key Lab Tobacco Chem Yunnan Prov, Kunming 650231, Yunnan, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2020年 / 56卷 / 01期

基金：

中国国家自然科学基金;

关键词：

chromone derivatives; Cassia nomame; anti-tobacco mosaic virus (anti-TMV) activity; PURGATIVE CRUDE DRUGS; FISTULA; CONSTITUENTS;

D O I：

10.1007/s10600-020-02943-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new chromone derivatives, 5-(isobutyryl)-2-(2-oxopropyl)-7-methoxy-4H-chromen-4-one (1) and 5-(isobutyryl)-2-(2-oxopropyl)-6-methoxy-4H-chromen-4-one (2), were isolated from Cassia nomame. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1 and 2 showed potential anti-TMV activities with inhibition rates of 28.7% and 31.2%, at the concentration of 20 mu M, respectively. These rates are close to that of positive control.

引用

页码：58 / 61

页数：4

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