Ugi-4-Component Reaction Enabling Rapid Access to the Core Fragment of Massadine

被引：32

作者：

Chinigo, Gary M. ^{[1
]}

Breder, Alexander ^{[1
]}

Carreira, Erick M. ^{[1
]}

机构：

[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 01期

关键词：

EXCLUSIVE REGIOSELECTIVE FRAGMENTATION; REMOTE CARBONYL GROUPS; DIELS-ALDER REACTIONS; STEREOCONTROLLED SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; RADICAL DECARBOXYLATION; MARINE ALKALOIDS; NAGELAMIDE-E; PALAUAMINE; OZONOLYSIS;

D O I：

10.1021/ol102577q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid method to access the densely functionalized core structure of massadine (1) has been developed. The use of the Ugi-4-component reaction involving a convertible isonitrile and an end-group differentiating ozonolysis constitute the key operations toward the synthesis of the D-ring subunit.

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页码：78 / 81

页数：4

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