Simultaneous estimation of levofloxacin hemihydrate and ornidazole in tablet dosage form by HPTLC

被引：0

作者：

Surendra, K. ^{[1
]}

Mageswari, S. D. ^{[1
]}

Maheswari, R. ^{[1
]}

Harikrishnan, N. ^{[1
]}

Roosewelt, C. ^{[1
]}

Gunasekaran, V. ^{[1
]}

机构：

[1] Vels Coll Pharm, Dept Pharmaceut Anal, Madras 600117, Tamil Nadu, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2007年 / 19卷 / 07期

关键词：

levofloxacin hemihydrate; ornidazole; HPTLC; estimation;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A validated HPTLC method for simultaneous estimation of levofloxacin hemihydrate and ornidazole in tablet formulations is described. Separation was achieved on precoated silica gel plate 60 F-254 using n-butan ol: water: gl aceal acetic acid (60:20:20) as mobile phase. Quantitation was carried out by the use of densitometer in absorbance mode at 366 nm. Linearity of detector response for levofloxacin hemihydrate and ornidazole estimated in the average weight of the tablet were found to be 99.7 and 100.45 %, respectively. The proposed method is accurate, precise and reproducible and can be adopted for routine analysis of levofloxacin hemihydrate and ornidazole in tablet formulation.

引用

页码：5647 / 5651

页数：5

共 7 条

[1]

ADAMOUICS AJ, CHROMATOGRAPHIC ANAL, V74, P5

[2] The ICH guidance in practice: stress degradation studies on ornidazole and development of a validated stability-indicating assay [J].

Bakshi, M ;

Singh, B ;

Singh, A ;

Singh, S .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2001, 26 (5-6) :891-897

[3]

FU CN, 2000, CHIN J PHARM ANAL, P373

[4]

LI Q, 2003, CHIN PHARM J, V38, P69

[5] Determination of ornidazole in pharmaceutical dosage forms based on reduction at an activated glassy carbon electrode [J].

Ozkan, SA ;

Senturk, Z ;

Biryol, I .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 157 (02) :137-144

[6]

SETHI PD, 1996, HPTLC QUANTITATIVE, V1, P1

[7]

ZHANG HW, 1998, J CHIN PHARM, V9, P28

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