The Tumor Suppressor LKB1 Emerges as a Critical Factor in Hematopoietic Stem Cell Biology

被引：19

作者：

Krock, Bryan ^{[1
]}

Skuli, Nicolas ^{[1
,2
]}

Simon, M. Celeste ^{[1
,2
,3
]}

机构：

[1] Univ Penn, Sch Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

来源：

CELL METABOLISM | 2011年 / 13卷 / 01期

关键词：

METABOLISM; NICHE;

D O I：

10.1016/j.cmet.2010.12.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

How cellular metabolism regulates stem cell function is poorly understood but is an emerging field of study. In a recent issue of Nature, three independent groups demonstrate that LKB1 promotes hematopoietic stem cell (HSC) quiescence and metabolic homeostasis. Surprisingly, these effects on HSCs occur independently of AMPK/mTOR and FoxO signaling.

引用

页码：8 / 10

页数：3

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