Thermal study of pazopanib hydrochloride

被引：9
作者：
Herbrink, Maikel [1 ,2 ]
Schellens, Jan [1 ,2 ,3 ]
Beijnen, Jos [1 ,2 ,3 ]
Nuijen, Bastiaan [1 ,2 ]
机构：
[1] Netherlands Canc Inst, Dept Pharm & Pharmacol, Antoni van Leeuwenhoek Hosp, Louwesweg 6, NL-1066 EC Amsterdam, Netherlands
[2] MC Slotervaart, Louwesweg 6, NL-1066 EC Amsterdam, Netherlands
[3] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Sci Fac, Div Pharmacoepidemiol & Clin Pharmacol, Univ Weg 99, NL-3584 CG Utrecht, Netherlands
来源：
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2017年 / 130卷 / 03期
关键词：
Pazopanib hydrochloride; Thermal analysis; Physicochemical characterization; Preformulation; KINETIC-ANALYSIS; NONISOTHERMAL CONDITIONS; DECOMPOSITION; BIOAVAILABILITY; TEMPERATURE; DEGRADATION; BEHAVIOR;
D O I：
10.1007/s10973-017-6286-4
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
The currently marketed formulation of pazopanib hydrochloride has a poor bioavailability and pharmacokinetic profile. An alternative formulation of the drug might have an improved performance. Knowledge about the thermal behavior of the drug may be instrumental in the development process of such a formulation. The aim of this study was to thermally characterize raw bulk drug material of the multiple kinase inhibitor pazopanib hydrochloride using different analytical techniques. Solid-state characterization was carried out with Fourier transform infrared spectroscopy and X-ray diffraction. Thermal characterization was performed with thermogravimetric analysis and differential scanning calorimetry. Thermal and thermodynamic parameters were assessed using the Ozawa-Flynn-Wall, Friedman and Kissinger-Akahira-Sunose isoconversional methods.
引用
收藏
页码：1491 / 1499
页数：9
相关论文
共 36 条
[1]   Measurement of Cracking Kinetics of Pure Model Compounds by Thermogravimetric Analysis [J].
Alshareef, Ali H. ;
Azyat, Khalid ;
Tykwinski, Rik R. ;
Gray, Murray R. .
ENERGY & FUELS, 2010, 24 (07) :3998-4004
[2]   Study on the Thermooxidative Degradation Kinetics of Tetrafluoroethylene-Ethylene Copolymer Filled with Rice Husks Ash [J].
Atanassov, Atanass ;
Genieva, Svetlana ;
Vlaev, Lyubomir .
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING, 2010, 49 (06) :541-554
[3]   Thermoanalytical Investigation of Terazosin Hydrochloride [J].
Attia, Ali Kamal ;
Abdel-Moety, Mona Mohamed .
ADVANCED PHARMACEUTICAL BULLETIN, 2013, 3 (01) :147-152
[4]   A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry [J].
Bibi, S. ;
Bremner, D. H. ;
Macdougall-Heasman, M. ;
Reid, R. ;
Simpson, K. ;
Tough, A. ;
Waddell, S. ;
Stewart, I. J. ;
Matthews, K. H. .
ANALYTICAL METHODS, 2015, 7 (20) :8597-8604
[5]   Kinetics and Thermodynamics of the Formation of MnFeP4O12 [J].
Boonchom, Banjong ;
Thongkam, Montree .
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2010, 55 (01) :211-216
[6]  
Chava S, 2014, IMPROVED PROCESS PRE
[7]   Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer [J].
Deng, Yanli ;
Sychterz, Caroline ;
Suttle, A. Benjamin ;
Dar, Mohammed M. ;
Bershas, David ;
Negash, Kitaw ;
Qian, Yanwen ;
Chen, Emile P. ;
Gorycki, Peter D. ;
Ho, May Y. K. .
XENOBIOTICA, 2013, 43 (05) :443-453
[8]   Sodium alendronate used in bone treatment [J].
Doca, Sorin Cristian ;
Albu, Paul ;
Ceban, Iulia ;
Anghel, Andrei ;
Vlase, Gabriela ;
Vlase, Titus .
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2016, 126 (01) :189-194
[9]  
European Medicines Agency (EMA), 2011, ASS REP VOTR EPAR
[10]  
European Medicines Agency (EMA), 2016, SUMM PROD CHAR VOTR
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