Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis

被引：11

作者：

Hirvasniemi, J. ^{[1
]}

Thevenot, J. ^{[2
,3
]}

Multanen, J. ^{[4
]}

Haapea, M. ^{[2
,5
,6
]}

Heinonen, A. ^{[7
]}

Nieminen, M. T. ^{[2
,3
,5
,6
]}

Saarakkala, S. ^{[2
,3
,5
,6
]}

机构：

[1] Univ Oulu, Fac Informat Technol & Elect Engn, Ctr Machine Vis & Signal Anal, POB 4500, FI-90014 Oulu, Finland

[2] Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland

[3] Univ Oulu, Infotech Oulu, Oulu, Finland

[4] Cent Finland Cent Hosp, Dept Phys Med & Rehabil, Jyvaskyla, Finland

[5] Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland

[6] Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland

[7] Univ Jyvaskyla, Fac Sports & Hlth Sci, Jyvaskyla, Finland

来源：

OSTEOARTHRITIS AND CARTILAGE | 2017年 / 25卷 / 12期

基金：

芬兰科学院; 欧洲研究理事会;

关键词：

Radiography; MRI; Osteoarthritis; Bone structure; Cartilage composition; Knee; FEMORAL-NECK FRACTURE; ARTICULAR-CARTILAGE; TRABECULAR BONE; TEXTURE ANALYSIS; QUANTITATIVE MRI; 3-DIMENSIONAL MICROARCHITECTURE; PLAIN RADIOGRAPHS; MINERAL DENSITY; KNEE; PROGRESSION;

D O I：

10.1016/j.joca.2017.09.008

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: Our aim was to investigate the relation between radiograph-based subchondral bone structure and cartilage composition assessed with delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T-2 relaxation time. Design: Ninety-three postmenopausal women (Kellgren-Lawrence grade 0: n = 13, 1: n = 26, 2: n = 54) were included. Radiograph-based bone structure was assessed using entropy of the Laplacian-based image (E-Lap) and local binary patterns (E-LBP), homogeneity indices of the local angles (HIAngles,mean, HIAngles,Perp, HIAngles,Paral), and horizontal (FDHor) and vertical fractal dimensions (FDVer). Mean dGEMRIC index and T-2 relaxation time of tibial cartilage were calculated to estimate cartilage composition. Results: HIAngles,mean (r(s) = -0.22) and HIAngles, Paral (r(s) = -0.24) in medial subchondral bone were related (P < 0.05) to dGEMRIC index of the medial tibial cartilage. E-Lap (r(s) = -0.23), FDHor, (0.34 mm) (r = 0.21) and FDVer,0.68 mm (r = 0.24) in medial subchondral bone were related (P < 0.05) to T-2 relaxation time values of the medial tibial cartilage. FDHor at different scales in lateral subchondral bone were related (P < 0.01) to dGEMRIC index (r = 0.29-0.41) and T-2 values of lateral tibial cartilage (r = -0.28 to -0.36). FDVer at larger scales were related (P < 0.05) to dGEMRIC index (r = 0.24-0.25) and T-2 values of lateral tibial cartilage (r = -0.21). HIAngles, Paral (r = -0.25) and FDVer, (0.68 mm) (r(s) = 0.22) in the lateral tibial trabecular bone were related (P < 0.05) to dGEMRIC index of the lateral tibial cartilage. Conclusion: Our results support the presumption that several tissues are affected in the early osteoarthritis (OA). Furthermore, they indicate that the detailed analysis of radiographs may serve as a complementary imaging tool for OA studies. (C) 2017 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.

引用

页码：2039 / 2046

页数：8

共 41 条

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