Substance P (SP) and vasoactive intestinal polypeptide (VIP) in the lower uterine segment in first and repeated cesarean sections

被引:12
作者
Malvasi, Antonio [2 ]
Tinelli, Andrea [1 ]
Cavallotti, Carlo [3 ]
Bettocchi, Stefano [4 ]
Di Renzo, Gian Carlo [5 ]
Stark, Michael [6 ]
机构
[1] Vito Fazzi Hosp, Dept Obstet & Gynecol, Div Expt Endoscop Surg Imaging Technol & Minimall, I-73100 Lecce, Italy
[2] Hosp Santa Maria, Dept Obstet & Gynecol, Bari, Italy
[3] Univ Roma La Sapienza, Dept Cardiovasc & Resp Sci, Rome, Italy
[4] Univ Bari, Dept Obstet Gynecol & Neonatol, Unit Obstet & Gynaecol 2, Bari, Italy
[5] Univ Perugia, Dept Obstet & Gynecol, I-06100 Perugia, Italy
[6] NESA, Berlin, Germany
关键词
Cesarean section; Substance P (SP); Vasoactive intestinal polypeptide (VIP); Labor; Neurotransmitters; Neuropeptides; Delivery; VBAC; Misgav Ladach cesarean section; RAT UTERUS; ADENYLYL-CYCLASE; SENSORY NERVES; GENITAL-TRACT; PEPTIDE VIP; PREGNANCY; EXPRESSION; FEMALE; CERVIX; NEURONS;
D O I
10.1016/j.peptides.2010.07.025
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The authors studied the presence of substance P (SP) and vasoactive intestinal polypeptide (VIP) and their related fibers in the lower uterine segment (LUS) in 133 women undergoing cesarean sections (CS) during active labor These were divided into 2 groups women undergoing repeat or first CSs Specimens were collected from the LUS and were evaluated by light microscopy and by immunohistochemistry for the morphometrical quantification of the SP and VIP fibers in the LUS The SP amount was higher in the post-CS scar while the VIP amount decreased nerve fibers contained an SP amount of up to 13 +/- 2 6 C U while nerve fibers contained a VIP amount of up to 7 +/- 1 9 C U The SP amount counts 10 +/- 1 5% of the total Bodian fibers and the ratio of the VIP is 10 +/- 1 8% of their total amount In normal conditions only 661 C U of the Bodian surface is occupied by SP related nerve fibers in contrast to 663 C U of the total surface by VIP the amount of SP increased up to 13 +/- 2 6 C U while it decreased in the LUS previous scars The SP levels are higher in repeat CS while the VIP levels are reduced in the LUS The Increase of SP is probably linked to the attempt to achieve cervical ripening in a post-CS LUS with the possible consequences of dystocia during vaginal birth after CS Nevertheless the decrease of VIP probably affects the relaxation of the internal uterine orifice compromising the LUS formation and cervical ripening (C) 2010 Elsevier Inc All rights reserved
引用
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页码:2052 / 2059
页数:8
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