Thrombin Expression in Prostate: A Novel Finding

被引：13

作者：

Kohli, Manish ^{[1
]}

Williams, Karin ^{[2
]}

Yao, Jorge L. ^{[3
]}

Dennis, Richard A. ^{[4
]}

Huang, Jiaoti ^{[5
]}

Reeder, Jay ^{[6
]}

Ricke, William A. ^{[7
]}

机构：

[1] Mayo Clin, Dept Oncol, Rochester, MN USA

[2] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH USA

[3] Univ Rochester, Med Ctr, Dept Pathol & Lab Med, Rochester, NY 14642 USA

[4] Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA

[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[6] SUNY Upstate Med Univ, Dept Urol, Syracuse, NY USA

[7] Univ Rochester, Med Ctr, Dept Urol & Pathol & Lab Med, Rochester, NY 14642 USA

来源：

CANCER INVESTIGATION | 2011年 / 29卷 / 01期

关键词：

MOLECULAR-WEIGHT HEPARIN; VENOUS THROMBOEMBOLISM; TISSUE FACTOR; CANCER; ACTIVATION; MALIGNANCY; SURVIVAL; DISEASE; METASTASIS; CARCINOMA;

D O I：

10.3109/07357907.2010.535057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. Methods: Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by immunohistochemistry of prostate tissue microarrays. Results: (Pro)thrombin mRNA expression was detected in cancer tissue and localized to prostatic epithelium and stroma by ISH. Thrombin protein was detected in stroma of benign and malignant epithelium (p <.05). Conclusions: Prostate tissue is a rich reservoir of thrombin. This may have potential for developing antithrombin-based cancer therapy.</.

引用

页码：62 / 67

页数：6

共 24 条

[1] Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brain [J].