Ferrier sulfonamidoglycosylation of D-glycals

被引：48

作者：

Colinas, Pedro A. ^{[1
]}

Bravo, Rodolfo D. ^{[1
]}

机构：

[1] Univ Nacl La Plata, Fac Ciencias Exactas, Dept Quim, LADECOR, RA-1900 La Plata, Argentina

来源：

CARBOHYDRATE RESEARCH | 2007年 / 342卷 / 15期

关键词：

sulfonamidoglycosylation; glycals; sulfonamides; ferrier rearrangement;

D O I：

10.1016/j.carres.2007.06.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel N-glycosyl sulfonamides were prepared via Ferrier sulfonamidoglycosylation of D-glycals with good to high alpha-stereo selectivity. Two new glycosylsulfamides were tested as carbonic anhydrase (CA II) inhibitors and showed good properties in the micromolar range. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2297 / 2302

页数：6

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