Activation-induced cytidine deaminase and active cytidine demethylation

被引：48
作者：
Ramiro, Almudena R. [1 ]
Barreto, Vasco M. [2 ]
机构：
[1] CNIC, Cell Biol Lab B, Madrid 28029, Spain
[2] Inst Gulbenkian Ciencias, Oeiras, Portugal
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2015年 / 40卷 / 03期
基金：
欧洲研究理事会;
关键词：
RNA EDITING ENZYME; DNA DEMETHYLATION; CYTOSINE DEAMINATION; AID EXPRESSION; MULLER GLIA; GENE; 5-METHYLCYTOSINE; HYPERMUTATION; PLURIPOTENCY; METHYLATION;
D O I：
10.1016/j.tibs.2015.01.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The regulation of demethylation in vertebrates has begun to be elucidated in the past decade. However, a possible involvement of activation-induced cytidine deaminase (AID) in this process remains uncertain. We survey the data supporting or casting doubt on such a role, and propose that there is no strong evidence for an involvement of AID in genome-wide active demethylation processes. Conversely, we present evidence that favors AID involvement in gene-specific demethylation events underlying cell differentiation.
引用
收藏
页码：172 / 181
页数：10
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