Towards a wearable near infrared spectroscopic probe for monitoring concentrations of multiple chromophores in biological tissue in vivo

被引:48
作者
Chitnis, Danial [1 ]
Airantzis, Dimitrios [1 ]
Highton, David [2 ]
Williams, Rhys [1 ]
Phong Phan [1 ]
Giagka, Vasiliki [1 ]
Powell, Samuel [1 ]
Cooper, Robert J. [1 ]
Tachtsidis, Ilias [1 ]
Smith, Martin [2 ]
Elwell, Clare E. [1 ]
Hebden, Jeremy C. [1 ]
Everdell, Nicholas [1 ]
机构
[1] UCL, Dept Med Phys & Biomed Engn, London WC1E 6BT, England
[2] Univ Coll London Hosp, Natl Hosp Neurol & Neurosurg, Neurocrit Care Unit, London WC1N 3BG, England
基金
英国惠康基金; 英国工程与自然科学研究理事会;
关键词
FNIRS; STIMULATION; OXYGENATION; HEMOGLOBIN; SYSTEM;
D O I
10.1063/1.4954722
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
The first wearable multi-wavelength technology for functional near-infrared spectroscopy has been developed, based on a custom-built 8-wavelength light emitting diode (LED) source. A lightweight fibreless probe is designed to monitor changes in the concentrations of multiple absorbers (chromophores) in biological tissue, the most dominant of which at near-infrared wavelengths are oxyhemoglobin and deoxyhemoglobin. The use of multiple wavelengths enables signals due to the less dominant chromophores to be more easily distinguished from those due to hemoglobin and thus provides more complete and accurate information about tissue oxygenation, hemodynamics, and metabolism. The spectroscopic probe employs four photodiode detectors coupled to a four-channel charge-to-digital converter which includes a charge integration amplifier and an analogue-to-digital converter (ADC). Use of two parallel charge integrators per detector enables one to accumulate charge while the other is being read out by the ADC, thus facilitating continuous operation without dead time. The detector system has a dynamic range of about 80 dB. The customized source consists of eight LED dies attached to a 2 mm x 2 mm substrate and encapsulated in UV-cured epoxy resin. Switching between dies is performed every 20 ms, synchronized to the detector integration period to within 100 ns. The spectroscopic probe has been designed to be fully compatible with simultaneous electroencephalography measurements. Results are presented from measurements on a phantom and a functional brain activation study on an adult volunteer, and the performance of the spectroscopic probe is shown to be very similar to that of a benchtop broadband spectroscopy system. The multi-wavelength capabilities and portability of this spectroscopic probe will create significant opportunities for in vivo studies in a range of clinical and life science applications. Published by AIP Publishing.
引用
收藏
页数:9
相关论文
共 23 条
[1]  
[Anonymous], 2009, P 2009 IFIP INT C WI, DOI DOI 10.1109/WOCN.2009.5010576
[2]   Optimal wavelength combinations for near-infrared spectroscopic monitoring of changes in brain tissue hemoglobin and cytochrome c oxidase concentrations [J].
Arifler, Dizem ;
Zhu, Tingting ;
Madaan, Sara ;
Tachtsidis, Ilias .
BIOMEDICAL OPTICS EXPRESS, 2015, 6 (03) :933-947
[3]   Brain mitochondrial oxidative metabolism during and after cerebral hypoxia-ischemia studied by simultaneous phosphorus magnetic-resonance and broadband near-infrared spectroscopy [J].
Bainbridge, A. ;
Tachtsidis, I. ;
Faulkner, S. D. ;
Price, D. ;
Zhu, T. ;
Baer, E. ;
Broad, K. D. ;
Thomas, D. L. ;
Cady, E. B. ;
Robertson, N. J. ;
Golay, X. .
NEUROIMAGE, 2014, 102 :173-183
[4]   A new broadband near-infrared spectroscopy system for in-vivo measurements of cerebral cytochrome-c-oxidase changes in neonatal brain injury [J].
Bale, Gemma ;
Mitra, Subhabrata ;
Meek, Judith ;
Robertson, Nicola ;
Tachtsidis, Ilias .
BIOMEDICAL OPTICS EXPRESS, 2014, 5 (10) :3450-3466
[5]   Imaging cognition II: An empirical review of 275 PET and fMRI studies [J].
Cabeza, R ;
Nyberg, L .
JOURNAL OF COGNITIVE NEUROSCIENCE, 2000, 12 (01) :1-47
[6]   Identification of the optimal wavelengths for optical topography: a photon measurement density function analysis [J].
Correia, Teresa ;
Gibson, Adam ;
Hebden, Jeremy .
JOURNAL OF BIOMEDICAL OPTICS, 2010, 15 (05)
[7]   A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application [J].
Ferrari, Marco ;
Quaresima, Valentina .
NEUROIMAGE, 2012, 63 (02) :921-935
[8]   Cerebral Near-Infrared Spectroscopy in Adults: A Work in Progress [J].
Ghosh, Arnab ;
Elwell, Clare ;
Smith, Martin .
ANESTHESIA AND ANALGESIA, 2012, 115 (06) :1373-1383
[9]   Noninvasive assessment of changes in cytochrome-c oxidase oxidation in human subjects during visual stimulation [J].
Heekeren, HR ;
Kohl, M ;
Obrig, H ;
Wenzel, R ;
von Pannwitz, W ;
Matcher, SJ ;
Dirnagl, U ;
Cooper, CE ;
Villringer, A .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1999, 19 (06) :592-603
[10]   Coupling Mechanism and Significance of the BOLD Signal: A Status Report [J].
Hillman, Elizabeth M. C. .
ANNUAL REVIEW OF NEUROSCIENCE, VOL 37, 2014, 37 :161-181