Genetic control of programmed cell death in Drosophila melanogaster

被引：56

作者：

Cashio, P ^{[1
]}

Lee, TV ^{[1
]}

Bergmann, A ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Genes & Dev Grad Program, Houston, TX 77030 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 02期

关键词：

drosophila; programmed cell death; apoptosis; Caspases; IAPs; drone; reaper; hid;

D O I：

10.1016/j.semcdb.2005.01.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Apoptosis is a genetically controlled form of cell death that is an important feature of animal development and homeostasis. The genes involved in the control and execution of apoptosis are conserved throughout evolution. However, the actual molecular mechanisms used by these genes vary from species to species. In this review, we focus on the genetic components of apoptosis in the fruit fly Drosophila melanogaster, and compare their mode of action to the one employed by the homologous genes in mammals. We also cover recent advances that show that apoptotic genes have a requirement in processes other than apoptosis. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：225 / 235

页数：11

共 102 条

[1]

ABRAMS JM, 1993, DEVELOPMENT, V117, P29

[2] Caspase activity and a specific cytochrome c are required for sperm differentiation in Drosophila [J].