A comparative study between limb-salvage and amputation for treating osteosarcoma

被引：62
作者：
Li, Xiaojuan [1 ]
Zhang, Ya [1 ]
Wan, Shanshan [2 ]
Li, Huiling [1 ]
Li, Dongqi [1 ]
Xia, Junfeng [1 ]
Yuan, Zhongqin [1 ]
Ren, Mingyan [1 ]
Yu, Shunling [1 ]
Li, Su [1 ]
Yang, Yihao [1 ]
Han, Lei [2 ]
Yang, Zuozhang [1 ]
机构：
[1] Kunming Med Univ, Tumor Hosp Yunnan Prov, Affiliated Hosp 3, Dept Orthoped, Kunming 650118, Peoples R China
[2] Kunming Med Univ, Affiliated Hosp 2, Dept Radiol, Kunming 650118, Peoples R China
来源：
JOURNAL OF BONE ONCOLOGY | 2016年 / 5卷 / 01期
基金：
中国博士后科学基金;
关键词：
Meta-analysis; Limb-salvage treatment; Amputation; Osteosarcoma; OF-THE-ART; PATHOLOGICAL FRACTURE; LOCALIZED OSTEOSARCOMA; NEOADJUVANT CHEMOTHERAPY; FUNCTIONAL OUTCOMES; OSTEOGENIC-SARCOMA; BONE-TUMOR; HIGH-GRADE; SURVIVAL; SURGERY;
D O I：
10.1016/j.jbo.2016.01.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: Osteosarcoma is an aggressive malignant neoplasm, and conflicting findings have been reported on the survival and function recovery in osteosarcoma patients experiencing limb salvage or amputation. In the present study, we compared clinical outcomes regarding limb salvage surgery vs. amputation for osteosarcoma patients by a meta-analysis. Method: Literature search was conducted in CNKI, Medline, Embase, the Cochrane Database, and Web of Sciences, and the quality of included studies was evaluated based on Newcastle-Ottawa scale quality assessment. Odds ratio and 95% confidence interval of the local recurrence, 5-year overall survival, and metastasis occurrence were calculated. Results: 17 articles were included according to selection criteria. There were 1343 patients in total derived from these studies. Our result showed that there was no significant difference between limb salvage surgery and amputation with respect to local recurrence, and patients with limb salvage surgery had a higher 5-year overall survival, and a lower metastasis occurrence. Conclusions: The present study provided more comprehensive evidences to support limb salvage surgery as an optimal treatment of osteosarcoma patients. (C) 2016 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license.
引用
收藏
页码：15 / 21
页数：7
相关论文
共 40 条
[1]   The surgical treatment and outcome of pathological fractures in localised osteosarcoma [J].
Abudu, A ;
Sferopoulos, NK ;
Tillman, RM ;
Carter, SR ;
Grimer, RJ .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1996, 78B (05) :694-698
[2]  
Allison D.C., 2011, SARCOMA, V2012, P1
[3]   Neoadjuvant chemotherapy for extremity osteosarcoma -: Preliminary results of the Rizzoli's 4th study [J].
Bacci, G ;
Ferrari, S ;
Mercuri, M ;
Longhi, A ;
Capanna, R ;
Tienghi, A ;
del Prever, AB ;
Comandone, A ;
Cesari, M ;
Bernini, G ;
Picci, P .
ACTA ONCOLOGICA, 1998, 37 (01) :41-48
[4]   Nonmetastatic osteosarcoma of the extremity with pathologic fracture at presentation - Local and systemic control by amputation or limb salvage after preoperative chemotherapy [J].
Bacci, G ;
Ferrari, S ;
Longhi, A ;
Donati, D ;
Manfrini, M ;
Giacomini, S ;
Briccoli, A ;
Forni, C ;
Galletti, S .
ACTA ORTHOPAEDICA SCANDINAVICA, 2003, 74 (04) :449-454
[5]   Osteosarcoma of the limb - Amputation or limb salvage in patients treated by neoadjuvant chemotherapy [J].
Bacci, G ;
Ferrari, S ;
Lari, S ;
Mercuri, M ;
Donati, D ;
Longhi, A ;
Forni, C ;
Bertoni, R ;
Versari, M ;
Pignotti, E .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2002, 84B :88-92
[6]   Do pathological fractures influence survival and local recurrence rate in bony sarcomas? [J].
Bramer, J. A. M. ;
Abudu, A. A. ;
Grimer, R. J. ;
Carter, S. R. ;
Tillman, R. M. .
EUROPEAN JOURNAL OF CANCER, 2007, 43 (13) :1944-1951
[7]   Prognostic factors in localized extremity osteosarcoma: A systematic review [J].
Bramer, J. A. M. ;
van Linge, J. H. ;
Grimer, R. J. ;
Scholten, R. J. P. M. .
EJSO, 2009, 35 (10) :1030-1036
[8]   Impairment and disability following limb salvage procedures for bone sarcoma [J].
Carty, Christopher P. ;
Dickinson, Ian C. ;
Watts, Mark C. ;
Crawford, Ross W. ;
Steadman, Peter .
KNEE, 2009, 16 (05) :405-408
[9]   OSTEOGENIC SARCOMA - A CRITICAL ANALYSIS OF 430 CASES [J].
COVENTRY, MB ;
DAHLIN, DC .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1957, 39 (04) :741-758
[10]   Two Case-Reports of the Limb Salvage Treatment of Osteosarcoma Consolidated with Obvious Pathological Fractures [J].
Cui, Q. ;
Li, D. F. ;
Liu, C. ;
Guo, J. ;
Liu, S. B. ;
Liu, Y. S. ;
Zhai, J. M. ;
Zeng, Yanjun .
PATHOLOGY & ONCOLOGY RESEARCH, 2011, 17 (04) :973-979
1234