A 48-channel receive array coil for mesoscopic diffusion-weighted MRI of ex vivo human brain on the 3 T connectome scanner

被引：16

作者：

Scholz, Alina ^{[1
]}

Etzel, Robin ^{[1
]}

May, Markus W. ^{[1
]}

Mahmutovic, Mirsad ^{[1
]}

Tian, Qiyuan ^{[2
,3
]}

Ramos-Llorden, Gabriel ^{[2
,3
]}

Maffei, Chiara ^{[2
,3
]}

Bilgic, Berkin ^{[2
,3
,4
]}

Witzel, Thomas ^{[2
,3
]}

Stockmann, Jason P. ^{[2
,3
]}

Mekkaoui, Choukri ^{[2
,3
]}

Wald, Lawrence L. ^{[2
,3
,4
]}

Huang, Susie Yi ^{[2
,3
,4
]}

Yendiki, Anastasia ^{[2
,3
]}

Keil, Boris ^{[1
,5
]}

机构：

[1] TH Mittelhessen Univ Appl Sci THM, Inst Med Phys & Radiat Protect IMPS, 14 Wiesenstr, D-35390 Giessen, Germany

[2] Massachusetts Gen Hosp, Dept Radiol, AA Martins Ctr Biomed Imaging, Boston, MA USA

[3] Harvard Med Sch, Boston, MA 02115 USA

[4] Harvard Mit Div Hlth Sci & Technol, Cambridge, MA USA

[5] Ctr Mind Brain & Behav CMBB, Marburg, Germany

来源：

NEUROIMAGE | 2021年 / 238卷

基金：

美国国家卫生研究院;

关键词：

Magnetic resonance imaging; Diffusion-weighted imaging; RF coil; Receive array coil; Brain imaging; Ex vivo brain; SIGNAL; STATE;

D O I：

10.1016/j.neuroimage.2021.118256

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In vivo diffusion-weighted magnetic resonance imaging is limited in signal-to-noise-ratio (SNR) and acquisition time, which constrains spatial resolution to the macroscale regime. Ex vivo imaging, which allows for arbitrarily long scan times, is critical for exploring human brain structure in the mesoscale regime without loss of SNR. Standard head array coils designed for patients are sub-optimal for imaging ex vivo whole brain specimens. The goal of this work was to design and construct a 48-channel ex vivo whole brain array coil for high-resolution and high b-value diffusion-weighted imaging on a 3T Connectome scanner. The coil was validated with bench measurements and characterized by imaging metrics on an agar brain phantom and an ex vivo human brain sample. The two-segment coil former was constructed for a close fit to a whole human brain, with small receive elements distributed over the entire brain. Imaging tests including SNR and G-factor maps were compared to a 64-channel head coil designed for in vivo use. There was a 2.9-fold increase in SNR in the peripheral cortex and a 1.3-fold gain in the center when compared to the 64-channel head coil. The 48-channel ex vivo whole brain coil also decreases noise amplification in highly parallel imaging, allowing acceleration factors of approximately one unit higher for a given noise amplification level. The acquired diffusion-weighted images in a whole ex vivo brain specimen demonstrate the applicability and advantage of the developed coil for high-resolution and high b-value diffusion-weighted ex vivo brain MRI studies.

引用

页数：14

共 61 条

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