Ether-a-go-go-Related gene potassium channels:: What's all the buzz about?

被引：41
作者：
Shepard, Paul D.
Canavier, Carmen C.
Levitan, Edwin S.
机构：
[1] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA
[2] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21228 USA
[3] Louisiana State Univ, Hlth Sci Ctr, Neurosci Ctr Excellence, New Orleans, LA 70112 USA
[4] Louisiana State Univ, Hlth Sci Ctr, Dept Ophthalmol, New Orleans, LA 70112 USA
[5] Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA
来源：
SCHIZOPHRENIA BULLETIN | 2007年 / 33卷 / 06期
关键词：
schizophrenia; bursting; dopamine; antipsychotic drugs; review;
D O I：
10.1093/schbul/sbm106
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Antipsychotic drugs are thought to exert their therapeutic action by antagonizing dopamine receptors but are also known to produce side effects in the heart by inhibiting cardiac ether-a-go-go-related gene (ERG) K+ channels. Recently, it has been discovered that the same channels are present in the brain, including midbrain dopamine neurons. ERG channels are most active after the cessation of intense electrical activity, and blockade of these channels prolongs plateau potentials in bursting dopamine neurons. This change in excitability would be expected to alter dopamine release. Therefore, the therapeutic action of antipsychotic drugs may depend on inhibition of both postsynaptic dopamine receptors and presynaptic ERG K+ channels.
引用
收藏
页码：1263 / 1269
页数：7
相关论文
共 64 条
[1]   Hyperpolarizing after-potentials regulate generation of long-duration plateau depolarizations in rat paraventricular nucleus neurons [J].
Bains, JS ;
Ferguson, AV .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 (04) :1412-1421
[2]   A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs [J].
Bauer, CK ;
Schäfer, R ;
Schiemann, D ;
Reid, G ;
Hanganu, I ;
Schwarz, JR .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1999, 148 (1-2) :37-45
[3]   Drug-induced block of cardiac HERG potassium channels and development of torsade de pointes arrhythmias:: the case of antipsychotics [J].
Calderone, V ;
Testai, L ;
Martinotti, E ;
Del Tacca, M ;
Breschi, MC .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2005, 57 (02) :151-161
[4]  
CANAVIER CC, 2007, J NEUROPHYSIOL
[5]   DOPAMINE RECEPTOR-BINDING PREDICTS CLINICAL AND PHARMACOLOGICAL POTENCIES OF ANTI-SCHIZOPHRENIC DRUGS [J].
CREESE, I ;
BURT, DR ;
SNYDER, SH .
SCIENCE, 1976, 192 (4238) :481-483
[6]   Effects of antipsychotic drugs on Ito, INa, Isus, IK1, and hERG:: QT prolongation, structure activity relationship, and network analysis [J].
Crumb, William J., Jr. ;
Ekins, Sean ;
Sarazan, R. Dustan ;
Wikel, James H. ;
Wrighton, Steven A. ;
Carlson, Christopher ;
Beasley, Charles M., Jr. .
PHARMACEUTICAL RESEARCH, 2006, 23 (06) :1133-1143
[7]   A MOLECULAR-BASIS FOR CARDIAC-ARRHYTHMIA - HERG MUTATIONS CAUSE LONG QT SYNDROME [J].
CURRAN, ME ;
SPLAWSKI, I ;
TIMOTHY, KW ;
VINCENT, GM ;
GREEN, ED ;
KEATING, MT .
CELL, 1995, 80 (05) :795-803
[8]   Biology of cardiac arrhythmias - Ion channel protein trafficking [J].
Delisle, BP ;
Anson, BD ;
Rajamani, S ;
January, CT .
CIRCULATION RESEARCH, 2004, 94 (11) :1418-1428
[9]   Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel [J].
Ekins, S ;
Crumb, WJ ;
Sarazan, RD ;
Wikel, JH ;
Wrighton, SA .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 301 (02) :427-434
[10]   Firing dynamics of cerebellar Purkinje cells [J].
Fernandez, Fernando R. ;
Engbers, Jordan D. T. ;
Turner, Ray W. .
JOURNAL OF NEUROPHYSIOLOGY, 2007, 98 (01) :278-294
1234567