Are There Knots in Chromosomes?

被引：28

作者：

Siebert, Jonathan T. ^{[1
]}

Kivel, Alexey N. ^{[1
]}

Atkinson, Liam P. ^{[2
]}

Stevens, Tim J. ^{[3
]}

Laue, Ernest D. ^{[2
]}

Virnau, Peter ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Phys, Staudinger Weg 9, D-55128 Mainz, Germany

[2] Univ Cambridge, Dept Biochem, 80 Tennis Court Rd, Cambridge CB2 1GA, England

[3] MRC Lab Mol Biol, Francis Crick Ave,Cambridge Biomed Campus, Cambridge CB2 0QH, England

来源：

POLYMERS | 2017年 / 9卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

knots; chromosomes; chromosome territories; DNA; fractal globule; PHAGE CAPSIDS; DNA-MOLECULES; MITOTIC CHROMOSOMES; HUMAN GENOME; ORGANIZATION; CHROMATIN; PROTEIN; PRINCIPLES; TOPOISOMERASES; ARCHITECTURE;

D O I：

10.3390/polym9080317

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Recent developments have for the first time allowed the determination of three-dimensional structures of individual chromosomes and genomes in nuclei of single haploid mouse embryonic stem (ES) cells based on Hi-C chromosome conformation contact data. Although these first structures have a relatively low resolution, they provide the first experimental data that can be used to study chromosome and intact genome folding. Here we further analyze these structures and provide the first evidence that G1 phase chromosomes are knotted, consistent with the fact that plots of contact probability vs sequence separation show a power law dependence that is intermediate between that of a fractal globule and an equilibrium structure.

引用

页数：10

共 48 条

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