The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans: evolutionary aspects, epidemiology and etiological role in aggressive periodontitis

被引：55
作者：
Haubek, Dorte [1 ]
机构：
[1] Aarhus Univ, Fac Hlth Sci, Sch Dent, DK-8000 Aarhus C, Denmark
来源：
APMIS | 2010年 / 118卷
关键词：
POLYMERASE-CHAIN-REACTION; LOCALIZED JUVENILE PERIODONTITIS; EARLY-ONSET PERIODONTITIS; ORAL ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; CYTOLETHAL DISTENDING TOXIN; PLASMID-CONTAINING STRAINS; HUMORAL IMMUNE-RESPONSE; BUCCAL EPITHELIAL-CELLS; NECROSIS-FACTOR-ALPHA; RIBOSOMAL-RNA GENE;
D O I：
10.1111/j.1600-0463.2010.02665.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
For many years, attention has been given to the oral bacterium Aggregatibacter actinomycetemcomitans, as a species possibly implicated in the etiology of aggressive periodontitis in adolescents. One of the major virulence factors of A. actinomycetemcomitans is the leukotoxin which is able to kill important cells of the immune system. © 2010 APMIS.
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页码：1 / 53
页数：53
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