Solvent-free synthesis of functionalized flavones under microwave irradiation

被引：110
|
作者：
Seijas, JA [1 ]
Vázquez-Tato, MP [1 ]
Carballido-Reboredo, R [1 ]
机构：
[1] Univ Santiago de Compostela, Fac Ciencias, Dept Quim Organ, Lugo 27080, Spain
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 07期
关键词：
D O I：
10.1021/jo048685z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Eco-friendly direct solvent-free synthesis of flavones is achieved by microwave irradiation of phloroglucinol and beta-ketoesters. Heating with microwaves versus under classical conditions was shown to be higher yielding, cleaner, and faster. The reaction goes through a cycloaddition of an alpha-oxo ketene intermediate followed by an uncatalyzed thermal Fries rearrangement.
引用
收藏
页码：2855 / 2858
页数：4
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