Cholinergic modulation of the hippocampal region and memory fuction

被引：302

作者：

Haam, Juhee ^{[1
]}

Yakel, Jerrel L. ^{[1
]}

机构：

[1] NIEHS, Neurobiol Lab, NIH, Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 2017年 / 142卷

关键词：

ACh; AD; cholinergic; hippocampus; learning; memory; muscarinic; nicotinic; NICOTINIC ACETYLCHOLINE-RECEPTORS; LONG-TERM POTENTIATION; RAT DENTATE GYRUS; ALZHEIMERS-DISEASE; BASAL FOREBRAIN; ACH RECEPTORS; WORKING-MEMORY; TRANSDERMAL NICOTINE; ENTORHINAL CORTEX; CA1; REGION;

D O I：

10.1111/jnc.14052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acetylcholine (ACh) plays an important role in memory function and has been implicated in aging-related dementia, in which the impairment of hippocampus-dependent learning strongly manifests. Cholinergic neurons densely innervate the hippocampus, mediating the formation of episodic as well as semantic memory. Here, we will review recent findings on acetylcholine's modulation of memory function, with a particular focus on hippocampus-dependent learning, and the circuits involved. In addition, we will discuss the complexity of ACh actions in memory function to better understand the physiological role of ACh in memory.

引用

页码：111 / 121

页数：11

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