Dose-response relationships

被引：0

作者：

Dickerson, RL ^{[1
]}

Brouwer, A ^{[1
]}

Gray, LE ^{[1
]}

Grothe, DR ^{[1
]}

Peterson, RE ^{[1
]}

Sheehan, DM ^{[1
]}

Sills-McMurry, C ^{[1
]}

Wiedow, MA ^{[1
]}

机构：

[1] Texas Tech Univ, TTUHSC, Lubbock, TX 79409 USA

来源：

PRINCIPLES AND PROCESSES FOR EVALUATING ENDOCRINE DISRUPTION IN SILDLIFE | 1998年

关键词：

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The quantification of dose-response (D-R) relationships is an essential part of ecological risk assessment. The same basic principles apply to D-R relationships for potential endocrine-disrupting chemicals (EDCs) as for any other potentially harmful xenobiotic compound. The primary difference in the endocrine system as a target organ is its degree of complexity, with many potential target sites and multiple levels of regulation. This complexity makes it difficult to choose how many and what types of endpoints to use. In designing studies to generate D-R curves for potential EDCs, it is important to select a number of doses to span the entire range of responses. These doses should be spaced closely enough to detect unusual D-R relationships such as U-shaped and inverted U-shaped D-R relationships. Current guidelines for reproductive testing in mammalian or avian species do not include a sufficient number of dose levels to generate adequate D-R relationships for determining the risk posed by potential EDCs. Sufficient data must be compiled in order to generate a benchmark dose (as used by the USEPA) for the potential endocrine-disrupting chemical for the level of ecological risk deemed acceptable.

引用

页码：69 / 96

页数：4