In vitro and in vivo comparison of the biological activities of two traditionally and widely used Arum species from Jordan: Arum dioscoridis Sibth & Sm. and Arum palaestinum Boiss.

被引：12
作者：
Afifi, Fatma U. [1 ]
Kasabri, Violet [1 ]
Litescu, Simona C. [2 ]
Abaza, Ismail M. [1 ]
机构：
[1] Univ Jordan, Fac Pharm, Amman, Jordan
[2] Natl Inst Biol Sci, Bucharest, Romania
来源：
NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 16期
关键词：
Arum dioscoridis Sibth & Sm; A. palaestinum Boiss; Araceae; HPLC-MS; pancreatic lipase and alpha-amylase; MEDICINAL-PLANTS; ALPHA-GLUCOSIDASE; LIPASE; EXTRACTS;
D O I：
10.1080/14786419.2015.1072713
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Arum dioscoridis and A. palaestinum (Araceae) are indigenous plant species in Jordan. HPLC-MS analysis of A. dioscoridis revealed the presence of apigenin, luteolin, quercetin, quercetin-3-O--glucoside, vitexin, isoorientin, esculin, and caffeic and ferulic acids. Both Arum spp., influenced gastrointestinal carbohydrate and lipid digestion and absorption. Orlistat inhibited dose dependently and highly substantially pancreatic lipase (PL) in vitro. Similar to orlistat, Arum species aqueous extracts (AEs), apigenin, caffeic acid and esculin exhibited a concentration related PL inhibition. Comparable to acarbose, dual inhibition of -amylase/-glucosidase was observed for both Arum species. Like guar gum, A. dioscoridis AE minimised substantially area under 24h glucose curve. Acute starch-induced postprandial hyperglycaemia in overnight fasting rats was highly significantly (p<0.001) decreased by A. dioscoridis AE. A. palaestinum could not perform effectively in either starch- or glucose-fed fasting rats. No antiproliferative effects against colorectal cancer cell lines HT29, HCT116 and SW620 were detected for tested Arum spp. [GRAPHICS] .
引用
收藏
页码：1777 / 1786
页数：10
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