The bad seed in Alzheimer's disease

被引：19

作者：

Fryer, JD ^{[1
]}

Holtzman, DM ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Hope Ctr Neurol Disorders, Dept Neurol & Mol Biol & Pharmacol, St Louis, MO 63110 USA

来源：

NEURON | 2005年 / 47卷 / 02期

关键词：

D O I：

10.1016/j.neuron.2005.07.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this issue of Neuron, McGowan et al. report on a new mouse model of amyloid deposition as occurs in Alzheimer's disease. Unlike previous models in which overexpression of the amyloid precursor protein results in amyloid plaque formation, McGowan et al. have produced mice that overexpress only A beta 40 or A beta 42 and prove that A beta 42 is critical for the formation of amyloid deposits in vivo.

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收藏

页码：167 / 168

页数：2

相关论文

共 12 条

[1]

Bales K R, 2002, Mol Interv, V2, P363, DOI 10.1124/mi.2.6.363

[2] Human apolipoprotein E4 alters the amyloid-β 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model [J].

Fryer, JD ;

Simmons, K ;

Parsadanian, M ;

Bales, KR ;

Paul, SM ;

Sullivan, PM ;

Holtzman, DM .

JOURNAL OF NEUROSCIENCE, 2005, 25 (11) :2803-2810

[3] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].

GLENNER, GG ;

WONG, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890

[4] AMYLOID-BETA PROTEIN (A-BETA) IN ALZHEIMERS-DISEASE BRAIN - BIOCHEMICAL AND IMMUNOCYTOCHEMICAL ANALYSIS WITH ANTIBODIES SPECIFIC FOR FORMS ENDING AT A-BETA-40 OR A-BETA-42(43) [J].

GRAVINA, SA ;

HO, LB ;

ECKMAN, CB ;

LONG, KE ;

OTVOS, L ;

YOUNKIN, LH ;

SUZUKI, N ;

YOUNKIN, SG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (13) :7013-7016

[5] Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics [J].

Hardy, J ;

Selkoe, DJ .

SCIENCE, 2002, 297 (5580) :353-356

[6] Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice [J].

Hsiao, K ;

Chapman, P ;

Nilsen, S ;

Eckman, C ;

Harigaya, Y ;

Younkin, S ;

Yang, FS ;

Cole, G .

SCIENCE, 1996, 274 (5284) :99-102

[7] VISUALIZATION OF A-BETA-42(43) AND A-BETA-40 IN SENILE PLAQUES WITH END-SPECIFIC A-BETA MONOCLONALS - EVIDENCE THAT AN INITIALLY DEPOSITED SPECIES IS A-BETA-42(43) [J].

IWATSUBO, T ;

ODAKA, A ;

SUZUKI, N ;

MIZUSAWA, H ;

NUKINA, N ;

IHARA, Y .

NEURON, 1994, 13 (01) :45-53

[8] Transgenic mouse models of Alzheimer's disease [J].

Janus, C ;

Westaway, D .

PHYSIOLOGY & BEHAVIOR, 2001, 73 (05) :873-886

[9] Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia [J].

Kim, SH ;

Wang, R ;

Gordon, DJ ;

Bass, J ;

Steiner, DF ;

Lynn, DG ;

Thinakaran, G ;

Meredith, SC ;

Sisodia, SS .

NATURE NEUROSCIENCE, 1999, 2 (11) :984-988

[10] Aβ42 is essential for parenchymal and vascular amyloid deposition in mice [J].

McGowan, E ;

Pickford, F ;

Kim, J ;

Onstead, L ;

Eriksen, J ;

Yu, C ;

Skipper, L ;

Murphy, MP ;

Beard, J ;

Das, P ;

Jansen, K ;

DeLucia, M ;

Lin, WL ;

Dolios, G ;

Wang, R ;

Eckman, CB ;

Dickson, DW ;

Hutton, M ;

Hardy, J ;

Golde, T .

NEURON, 2005, 47 (02) :191-199