Thymol, Benzofuranoid, and Phenylpropanoid Derivatives: Anti-inflammatory Constituents from Eupatorium cannabinum

被引：43

作者：

Chen, Jih-Jung ^{[1
]}

Tsai, Yun-Chen ^{[1
]}

Hwang, Tsong-Long ^{[2
]}

Wang, Tai-Chi ^{[1
]}

机构：

[1] Tajen Univ, Grad Inst Pharmaceut Technol, Pingtung 907, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 05期

关键词：

CYTOTOXIC SESQUITERPENE LACTONES; OCCURRING TERPENE DERIVATIVES; STRUCTURAL ELUCIDATION; TUMOR INHIBITORS; ARNICA-SACHALINENSIS; NEUTROPHILS; ROTUNDIFOLIUM; SEMISERRATUM; GLUTINOSUM; FLAVONOIDS;

D O I：

10.1021/np100923z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new compounds, 9-O-angeloyl-8,10-dehydrothymol (1), 9-(3-methylbutanoyl)-8,10-dehydrothymol (2), eupatobenzofuran (3), 2-hydroxy-2,6-dimethylbenzofuran-3 (2H)-one (4), and 1-(2-hydroxy-4-methylphenyl)propan-1,2-dione (5), have been isolated from the aerial part of Eupatorium cannabinum subsp. asiaticum, together with 16 known compounds (6-21). Compounds 6-8, 11, 13, and 15 exhibited inhibition (IC50 values <= 18.4 mu M) of superoxide anon generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 2, 3, 10, 13, and 15 inhibited fMLP/CB-induced elastase release with IC50 values <= 18.3 mu M.

引用

页码：1021 / 1027

页数：7

共 44 条

[1] A novel biotransformation of benzofurans and related compounds catalysed by a chloroperoxidase [J].

Alvarez, RG ;

Hunter, IS ;

Suckling, CJ ;

Thomas, M ;

Vitinius, U .

TETRAHEDRON, 2001, 57 (40) :8581-8587

[2] NATURALLY-OCCURRING TERPENE DERIVATIVES .358. 4 GUAIANOLIDES AND OTHER CONSTITUENTS FROM 3 KAUNIA SPECIES [J].

BOHLMANN, F ;

KRAMP, W ;

GUPTA, RK ;

KING, RM ;

ROBINSON, H .

PHYTOCHEMISTRY, 1981, 20 (10) :2375-2378

[3] NATURALLY-OCCURRING TERPENE DERIVATIVES .278. THYMOL DERIVATIVES FROM DORONICUM HUNGARICUM [J].

BOHLMANN, F ;

DHAR, AK ;

AHMED, M .

PHYTOCHEMISTRY, 1980, 19 (08) :1850-1851

[4]

BORREGAARD N, 1988, EUR J HAEMATOL, V41, P401

[5]

BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77

[6]

Chang Y. S., 2003, COMPENDIUM MED PLANT, P533

[7] Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils [J].

Chen, Jih-Jung ;

Tsai, Cheng-Shuan ;

Hwang, Tsong-Long ;

Shieh, Po-Chuen ;

Chen, Jinn-Fen ;

Sung, Ping-Jyun .

FOOD CHEMISTRY, 2010, 119 (03) :974-980

[8] Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils [J].

Chen, QD ;

Powell, DW ;

Rane, MJ ;

Singh, S ;

Butt, W ;

Klein, JB ;

McLeish, KR .

JOURNAL OF IMMUNOLOGY, 2003, 170 (10) :5302-5308

[9]

Chiu N. Y., 2001, ILLUSTRATED MED PLAN, V6, P235

[10] BIOGENETICALLY RELATED TRITERPENES FROM ELATERIOSPERMUM-TAPOS BARK [J].

CHOW, YL ;

QUON, HH .

PHYTOCHEMISTRY, 1970, 9 (05) :1151-+

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