When to initiate HIV therapy: A control theoretic approach

被引：61

作者：

Jeffrey, AM ^{[1
]}

Xia, XH ^{[1
]}

Craig, IK ^{[1
]}

机构：

[1] Univ Pretoria, Dept Elect Elect & Comp Engn Engn, ZA-0002 Pretoria, South Africa

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2003年 / 50卷 / 11期

关键词：

chemotherapy; controllability; HIV; initiate therapy; singular value;

D O I：

10.1109/TBME.2003.818465

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper shows an application of control theory to human immunodeficiency virus (HIV)/AIDS models. Minimum singular value decomposition,is applied to HIV/AIDS models to measure the extent to which the different stages in the progression of HIV/AIDS disease are controllable and, consequently, when best to initiate therapy such that the general objectives of therapy are satisfied. Simulations will be used to demonstrate the effect of treatment, at various stages. Comparisons will be made between mono-class and combination therapies and between when therapy is initiated at the acute infection, asymptomatic and the advanced stages.

引用

页码：1213 / 1220

页数：8

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