Tight regulation of the Epstein-Barr virus setpoint: Interindividual differences in Epstein-Barr virus DNA load are conserved after HIV infection

被引：12
作者：
Piriou, Erwan [1 ,2 ]
van Dort, Karel [1 ,2 ]
Otto, Sigrid [1 ,2 ]
van Oers, Marinus H. J. [3 ]
van Baarle, Debbie [1 ,2 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Clin Viroimmunol, Sanquin Res CLB, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Clin Viroimmunol, Landsteiner Lab, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Hematol, NL-1105 AZ Amsterdam, Netherlands
来源：
CLINICAL INFECTIOUS DISEASES | 2008年 / 46卷 / 02期
关键词：
D O I：
10.1086/524079
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Healthy individuals carry a constant number of Epstein-Barr virus-infected B cells in the peripheral blood over time. Here, we show that interindividual differences in Epstein-Barr virus DNA levels are maintained after HIV infection, providing evidence for the existence of an individual Epstein-Barr virus setpoint. Immune activation may contribute to the increase in this setpoint after human immunodeficiency virus seroconversion.
引用
收藏
页码：313 / 316
页数：4
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