Otx2 Promotes the Survival of Damaged Adult Retinal Ganglion Cells and Protects against Excitotoxic Loss of Visual Acuity In Vivo

被引：46

作者：

Ibad, Raoul Torero ^{[2
]}

Rheey, Jinguen ^{[2
]}

Mrejen, Sarah ^{[3
]}

Forster, Valerie ^{[4
,5
]}

Picaud, Serge ^{[4
,5
]}

Prochiantz, Alain ^{[1
,2
]}

Moya, Kenneth L. ^{[1
,2
]}

机构：

[1] Coll France, Ctr Interdisciplinary Res Biol, Dev & Neuropharmacol Grp,UMR 7241, INSERM,U1050,Chaire Proc Morphogenet,CNRS, F-75005 Paris, France

[2] Ecole Normale Super, Inst Biol, F-75005 Paris, France

[3] Ecole Normale Super, Dept Biol, CNRS, UMR 8542, F-75005 Paris, France

[4] Inst Vis, UMR S968, INSERM, F-75012 Paris, France

[5] Univ Paris 06, UMR S968, Inst Vis, F-75012 Paris, France

来源：

JOURNAL OF NEUROSCIENCE | 2011年 / 31卷 / 14期

关键词：

FACTOR 4E EIF4E; TRANSCRIPTION FACTOR; OPTIC-NERVE; NEUROFILAMENT SUBUNITS; AMACRINE CELLS; EXPRESSION; GLAUCOMA; DEGENERATION; APOPTOSIS; SUBSETS;

D O I：

10.1523/JNEUROSCI.0187-11.2011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Retinal ganglion cells (RGCs) are the projection neurons from the eye to the brain and their loss results in visual impairment in a number of diseases. Transcription factors with a homeodomain can translocate between cells and, in at least one reported case, can stimulate neuronal survival. Otx2 is a homeoprotein transcription factor expressed in the retina that is taken up by RGCs. We thus hypothesized that Otx2 capture could regulate the survival of adult RGCs. We report that Otx2 stimulates the survival of adult mouse and rat RGCs in vitro and protects RGCs against NMDA-induced toxicity in vivo in mice. In the latter model, Otx2 also preserves visual acuity.

引用

页码：5495 / 5503

页数：9

共 42 条

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