Secondary Metabolites from Marine Micromonospora: Chemistry and Bioactivities

被引：28

作者：

Qi, Sisi ^{[1
]}

Gui, Min ^{[2
,3
]}

Li, Huanhuan ^{[4
]}

Yu, Chunbo ^{[5
]}

Li, Hongji ^{[4
]}

Zeng, Zheling ^{[1
,6
,7
]}

Sun, Peng ^{[4
]}

机构：

[1] Nanchang Univ, Sch Resource & Environm & Chem Engn, 999 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China

[2] Bright Dairy & Food Co Ltd, State Key Lab Dairy Biotechnol, Technol Ctr, 1518 West Jiangchang Rd, Shanghai 200436, Peoples R China

[3] Bright Dairy & Food Co Ltd, Dairy Res Inst, 1518 West Jiangchang Rd, Shanghai 200436, Peoples R China

[4] Second Mil Med Univ, Sch Pharm, 325 Guohe Rd, Shanghai 200433, Peoples R China

[5] Jinhua Cent Hosp, Dept Pharm, 365 Renmin East Rd, Jinhua 321000, Zhejiang, Peoples R China

[6] Nanchang Univ, State Key Lab Food Sci & Technol, 999 Xuefu Ave, Nanchang 330047, Jiangxi, Peoples R China

[7] Nanchang Univ, Jiangxi Prov Key Lab Edible & Med Resources Explo, 999 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2020年 / 17卷 / 04期

基金：

中国国家自然科学基金;

关键词：

marine Micromonospora; secondary metabolites; natural products; biological activity; polyketide; ANTITUMOR-ACTIVITY; PHYSICOCHEMICAL PROPERTIES; TETROCARCIN CLASS; SP TP-A0316; A-C; ANTIBIOTICS; MACROLIDE; BIOSYNTHESIS; FERMENTATION; THIOCORALINE;

D O I：

10.1002/cbdv.202000024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Marine Micromonospora was revealed to be a rather untapped and a rich source of chemically diverse and unique bioactive natural products. This review is aimed to make a comprehensive survey of secondary metabolites that were derived from marine Micromonospora including chemical diversity and biological activities. A total of 116 compounds from 41 marine Micromonospora species have been reported, covering the literatures from 1997 to 2019. These compounds contain several structural classes such as polyketides (PKS), nonribosomal peptides (NRPS), PKS-NRPS hybrids, terpenes and others, and they present cytotoxic, antibacterial, antiparasitic, chemopreventive or antioxidant activities.

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