Impulse Control: Temporal Dynamics in Gene Transcription

被引：207

作者：

Yosef, Nir ^{[1
,2
]}

Regev, Aviv ^{[1
,3
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge Ctr 7, Cambridge, MA 02142 USA

[2] Harvard Univ, Sch Med, Ctr Neurol Dis, Brigham & Womens Hosp, Boston, MA 02115 USA

[3] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

CELL | 2011年 / 144卷 / 06期

关键词：

INCOHERENT FEEDFORWARD LOOP; NETWORK MOTIFS; SACCHAROMYCES-CEREVISIAE; ENVIRONMENTAL-CHANGES; REGULATORY NETWORKS; ESCHERICHIA-COLI; EXPRESSION RESPONSES; METABOLIC NETWORK; EUKARYOTIC GENOME; SYSTEMS BIOLOGY;

D O I：

10.1016/j.cell.2011.02.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulatory circuits controlling gene expression constantly rewire to adapt to environmental stimuli, differentiation cues, and disease. We review our current understanding of the temporal dynamics of gene expression in eukaryotes and prokaryotes and the molecular mechanisms that shape them. We delineate several prototypical temporal patterns, including "impulse" (or single-pulse) patterns in response to transient environmental stimuli, sustained (or state-transitioning) patterns in response to developmental cues, and oscillating patterns. We focus on impulse responses and their higher-order temporal organization in regulons and cascades and describe how core protein circuits and cis-regulatory sequences in promoters integrate with chromatin architecture to generate these responses.

引用

页码：886 / 896

页数：11

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