New Guaiane Sesquiterpene Lactones from Ixeris dentata

被引：21

作者：

Cha, Mi-Ran ^{[1
,2
]}

Choi, Yeon Hee ^{[1
]}

Choi, Chun Whan ^{[1
,2
]}

Yoo, Dae Seok ^{[1
,2
]}

Kim, Young Sup ^{[1
]}

Choi, Sang Un ^{[1
]}

Kim, Young Ho ^{[2
]}

Ryu, Shi Yong ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Taejon 305343, South Korea

[2] Chungnam Natl Univ, Coll Pharm, Taejon, South Korea

来源：

PLANTA MEDICA | 2011年 / 77卷 / 04期

关键词：

Ixeris dentate; Asteraceae; sesquiterpene lactone; cytotoxicity; tumor; GLYCOSIDES; GUAIANOLIDES; ANDRYALA;

D O I：

10.1055/s-0030-1250369

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new guaiane-type sesquiterpene lactones (1-3), together with nine related sesquiterpenes (4-12), were isolated from the whole extract of Ixeris dentata (Asteraceae). The chemical structures of isolates 1-12 were established by spectroscopic analyses as 3 beta,8 beta-dihydroxy-guaia-10(14)-en-1 alpha,4 alpha,5 alpha,6 beta,7 alpha,11 beta H-12, 6 alpha-olide (1), ixerin N 6'-O-acetate (2), ixerisoside A 6'-O-acetate (3), ixerin N(4), ixerisoside A(5), ixerin M (6), tectroside (7), 8-epidesacylcynaropicrin glucoside (8), 8-epiisolipidiol (9), 11 beta H-11, 13-dihydrointegrifolin (10) 8 beta-hydroxy-4 beta,15-dihydrozaluzanin C (11), and integrifolin (12). Compounds 1-12 were evaluated for their inhibitory effect on the proliferation of the cultured human tumor cell lines MES-SA, MES-SA/DX5, HCT-15, and HCT15/CL02 in vitro.

引用

页码：380 / 382

页数：3

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