Circular RNA has_circ_0003204 inhibits oxLDL-induced vascular endothelial cell proliferation and angiogenesis

被引：36

作者：

Liu, Huifang ^{[1
]}

Ma, Xirui ^{[1
]}

Mao, Ziming ^{[1
]}

Shen, Minyan ^{[1
]}

Zhu, Jing ^{[1
]}

Chen, Fengling ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Endocrinol & Metab, Shanghai, Peoples R China

来源：

CELLULAR SIGNALLING | 2020年 / 70卷

基金：

中国国家自然科学基金;

关键词：

Circular RNAs; circ_0003204; Atherosclerosis; ATHEROSCLEROSIS; MIGRATION;

D O I：

10.1016/j.cellsig.2020.109595

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Circular RNAs (circRNAs) are widely expressed in eukaryotic cells and play a key role in atherosclerosis. The aim of this study is to explore the relationship between hsa_circ_0003204 and atherosclerosis. Here, hsa_circ_0003204 was aberrantly overexpressed in the ox-LDL-induced human umbilical vein endothelial cells (HUVECs). Knockdown of hsa_circ_0003204 facilitated the proliferation, migration, and invasion but reduced the apoptosis of oxLDL-induced HUVECs. Furthermore, hsa_circ_0003204 knockdown significantly reduced the E-cadherin expression but increased the expressions of N-cadherin and vimentin in oxLDL-induced HUVECs. Collectively, these findings suggest that hsa_circ_0003204 plays an important role in the proliferation and angiogenesis of HUVECs, providing a potential target for treating endothelial cell damage in atherosclerosis.

引用

页数：5

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