Synthesis and colon anticancer activity of some novel thiazole/-2-quinolone derivatives

被引：35
作者：
Aly, Ashraf A. [1 ]
Mohamed, Asmaa H. [1 ]
Ramadan, Mohamed [2 ]
机构：
[1] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt
[2] Al Azhar Univ, Fac Pharm, Dept Organ Pharm, Assiut Branch, Assiut, Egypt
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2020年 / 1207卷
关键词：
2-Bromoacetophenones; Thiosemicarbazones; Thiazoles; Colon anticancer activity; QUINOLINE; ANTIOXIDANT; THIAZOLE; MOIETY; POTENT; SERIES; ETHYL; ACID;
D O I：
10.1016/j.molstruc.2020.127798
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We direct for the synthesis of 1,6,7-trisubstituted-4-phenylthiazol-2(3H)-ylidene)hydrazono)methyl) quinolin-2-one derivatives by the reaction of corresponding thiosemicarbazone derived by 2-quinolone derivatives with 2-bromoacetophenones in presence of triethylamine at room temperature. The mechanism of the formed products was discussed. The structure of the obtained products was fully characterized using different spectral techniques including infrared (IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS) together with elemental analyses. The new synthesized compounds showed a moderate colon anticancer activity. (C) 2020 Elsevier B.V. All rights reserved.
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页数：14
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