Interruption of HBV intrauterine transmission: A clinical study

被引:87
作者
Li, XM [1 ]
Yang, YB
Hou, HY
Shi, ZJ
Shen, HM
Teng, BQ
Li, AM
Shi, MF
Zou, L
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Obstet & Gynecol, Guangzhou 510630, Guangdong, Peoples R China
[2] Zhejiang Univ, Sch Med, Maternity Hosp, Hangzhou 310006, Zhejiang, Peoples R China
关键词
D O I
10.3748/wjg.v9.i7.1501
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To investigate the effect of hepatitis B virus (HBV) specific immunoglobin (HBIG) and lamivudine on HBV intrauterine transmission in HBsAg positive pregnant women. METHODS: Each subject in the HBIG group (56 cases) was given 200 IU HBIG intramuscularly (im.) every 4 weeks from 28-week (wk) of gestation, while each subject in the lamivudine group (43 cases) received 100 mg lamivudine orally (po.) every day from 28-wk of gestation until the 30(th) day after labor. Subjects in the control group (52 cases) received no specific treatment. Blood specimens were tested for HBsAg, HBeAg, and HBV-DNA in all maternities at 28-wk of gestation, before deliver)G and in their newborns 24 hours before the administration of immune prophylaxis. RESULTS: Reductions of HBV DNA in both treatments were significant (P<0.05). The rate of neonatal intrauterine HBV infection was significantly lower in HBIG group (16.1 %) and lamivudine group (16.3 %) compared with control group (32.7 %) (P<0.05), but there was no significant difference between HBIG group and lamivudine group (P>0.05). No side effects were found in all the pregnant women or their newborns. CONCLUSION: The risk of HBV intrauterine infection can be effectively reduced by administration of HBIG or Lamivudine in the 3(rd) trimester of HBsAg positive pregnant women.
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页码:1501 / 1503
页数:3
相关论文
共 34 条
[1]   Prenatal exposure to anti-HIV drugs - Long-term neurobehavioral effects of lamivudine (3TC) in CD-1 mice [J].
Calamandrei, G ;
Venerosi, A ;
Branchi, I ;
Valanzano, A ;
Alleva, E .
NEUROTOXICOLOGY AND TERATOLOGY, 2000, 22 (03) :369-379
[2]   REDUCTION OF MATERNAL-INFANT TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 WITH ZIDOVUDINE TREATMENT [J].
CONNOR, EM ;
SPERLING, RS ;
GELBER, R ;
KISELEV, P ;
SCOTT, G ;
OSULLIVAN, MJ ;
VANDYKE, R ;
BEY, M ;
SHEARER, W ;
JACOBSON, RL ;
JIMENEZ, E ;
ONEILL, E ;
BAZIN, B ;
DELFRAISSY, JF ;
CULNANE, M ;
COOMBS, R ;
ELKINS, M ;
MOYE, J ;
STRATTON, P ;
BALSLEY, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (18) :1173-1180
[3]   Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women [J].
Culnane, M ;
Fowler, M ;
Lee, SS ;
McSherry, G ;
Brady, M ;
O'Donnell, K ;
Mofenson, L ;
Gortmaker, SL ;
Shapiro, DE ;
Scott, G ;
Jimenez, E ;
Moore, EC ;
Diaz, C ;
Flynn, PM ;
Cunningham, B ;
Oleske, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (02) :151-157
[4]   FAILURE OF NEONATAL HEPATITIS-B VACCINATION - THE ROLE OF HBV-DNA LEVELS IN HEPATITIS-B CARRIER MOTHERS AND HLA ANTIGENS IN NEONATES [J].
DELCANHO, R ;
GROSHEIDE, PM ;
SCHALM, SW ;
DEVRIES, RRP ;
HEIJTINK, RA .
JOURNAL OF HEPATOLOGY, 1994, 20 (04) :483-486
[5]   A PRELIMINARY TRIAL OF LAMIVUDINE FOR CHRONIC HEPATITIS-B INFECTION [J].
DIENSTAG, JL ;
PERRILLO, RP ;
SCHIFF, ER ;
BARTHOLOMEW, M ;
VICARY, C ;
RUBIN, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (25) :1657-1661
[7]   Mother-to-child transmission of hepatitis B virus. Present knowledge and prevention. [J].
Hamdani-Belghiti, S ;
Bouazzaou, NL .
ARCHIVES DE PEDIATRIE, 2000, 7 (08) :879-882
[8]   Clinical pharmacokinetics of lamivudine [J].
Johnson, MA ;
Moore, KHP ;
Yuen, GJ ;
Bye, A ;
Pakes, GE .
CLINICAL PHARMACOKINETICS, 1999, 36 (01) :41-66
[9]   SIGNIFICANCE OF ISOLATED HEPATITIS-B CORE ANTIBODIES DETECTED BY ENZYME-IMMUNOASSAY IN A HIGH-RISK POPULATION [J].
KROES, ACM ;
QUINT, WGV ;
HEIJTINK, RA .
JOURNAL OF MEDICAL VIROLOGY, 1991, 35 (02) :96-100
[10]   Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: A placebo-controlled trial [J].
Lai, CL ;
Ching, CK ;
Tung, AKM ;
Li, E ;
Young, J ;
Hill, A ;
Wong, BCY ;
Dent, J ;
Wu, PC .
HEPATOLOGY, 1997, 25 (01) :241-244