Bacterial toxins that modulate host cell-cycle progression

被引:122
作者
Oswald, E
Nougayrède, JP
Taieb, F
Sugai, M
机构
[1] Ecole Natl Vet Toulouse, UMR1225, F-31076 Toulouse, France
[2] Grad Sch Biomed Sci, Dept Bacteriol, Hiroshima 7348553, Japan
基金
日本学术振兴会;
关键词
D O I
10.1016/j.mib.2004.12.011
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The mammalian cell cycle is involved in many processes such as immune responses, maintenance of epithelial barrier functions, and cellular differentiation - that affect the growth and colonization of pathogenic bacteria. Therefore it is not surprising that many bacterial pathogens manipulate the host cell cycle with respect to these functions. Cyclomodulins are a growing family of bacterial toxins and effectors that interfere with the eukaryotic cell cycle. Here, we review some of these cyclomodulins such as cytolethal distending toxins, vacuolating cytotoxin, the polyketide-derived macrolide mycolactone, cycle-inhibiting factor, cytotoxic necrotizing factors, dermonecrotic toxin, Pasteurella multocida toxin and cytotoxin-associated antigen A. We describe and compare their effects on the mammalian cell cycle and their putative role in disease, commensalism and symbiosis. We also discuss a possible link between these cyclomodulins and cancer.
引用
收藏
页码:83 / 91
页数:9
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