Spontaneous preterm birth in women with chronic hepatitis B virus infection

被引:35
作者
Elefsiniotis, Ioannis [1 ]
Tsoumakas, Konstantinos [2 ]
Vezali, Elena [1 ]
Glynou, Irene [3 ]
Drakoulis, Nikolaos [4 ,5 ]
Saroglou, George [1 ]
机构
[1] Elena Venizelou Hosp, Univ Dept Internal Med, Hepatol Unit, Athens, Greece
[2] Univ Athens, Dept Pediat, GR-10679 Athens, Greece
[3] Elena Venizelou Hosp, Dept Microbiol, Athens, Greece
[4] Univ Athens, Dept Pharm, GR-10679 Athens, Greece
[5] Res Diagnost Labs, Athens, Greece
关键词
Hepatitis B virus; HBV DNA; Hepatitis B surface antigen; Pregnancy; Preterm birth; PREGNANCY; DISEASE; EPIDEMIOLOGY; MECHANISMS; CARRIER; IMPACT;
D O I
10.1016/j.ijgo.2010.04.020
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine whether chronic hepatitis B virus (HBV) infection, as evidenced by serum levels of HBsAg and HBV DNA, is a risk factor for spontaneous preterrn birth (SPB). Method: The prevalence of HBV infection and the SPB rate were prospectively investigated among 1826 pregnant women, 30.89% Albanian and the remainder of other European origins. Results: Overall, 70 (3.8%) of the women were chronically infected with HBV. HBsAg status was strongly linked to SPB, which incurred to 5 (7.3%) of 64 women with circulating HBsAg compared with 28 (1.6%) of 1703 without current HBV infection (odds ratio, 5.2; P=0.007). SPB, however, was linked neither to HBsAg levels, nor to HBV DNA levels, nor to the presence or absence of viremia. Conclusion: Pregnant women were found to be at higher risk for SPB if they had circulating HBsAg, and the risk did not seem to be influenced by the levels of HBsAg or HBV DNA. (C) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:241 / 244
页数:4
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