Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet

被引:18
作者
Jambocus, Najla Gooda Sahib [1 ]
Ismail, Amin [2 ]
Khatib, Alfi [3 ]
Mahomoodally, Fawzi [4 ]
Saari, Nazamid [1 ]
Mumtaz, Muhammad Waseem [1 ,6 ]
Hamid, Azizah Abdul [1 ,5 ]
机构
[1] Univ Putra Malaysia, Fac Food Sci & Technol, Serdang, Malaysia
[2] Univ Putra Malaysia, Fac Med & Hlth Sci, Serdang, Malaysia
[3] Int Islamic Univ Malaysia, Kulliyyah Pharm, Dept Pharmaceut Chem, Kuantan, Malaysia
[4] Univ Mauritius, Fac Sci, Dept Hlth Sci, Reduit, Mauritius
[5] Univ Putra Malaysia, Halal Prod Res Inst, Serdang, Malaysia
[6] Univ Gujrat, Dept Chem, Gujrat, Pakistan
关键词
Morinda citrifolia; high fat diet; anti-obesity; pancreatic lipase; lipoprotein lipase; flavonoids; LIPASE INHIBITOR; OXIDATIVE STRESS; AQUEOUS EXTRACT; HUMAN OBESITY; VISCERAL FAT; LEPTIN; INSULIN; RUTIN; MICE; ANTIOXIDANTS;
D O I
10.1080/16546628.2017.1338919
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Background: Morinda citrifolia L. is widely used as a folk medicinal food plant to manage a panoply of diseases, though no concrete reports on its potential anti-obesity activity. This study aimed to evaluate the potential of M. citrifolia leaf extracts (MLE60) in the prevention of weight gain in vivo and establish its phytochemical profile. Design: Male Sprague-Dawley rats were divided into groups based on a normal diet (ND) or high fat diet (HFD), with or without MLE60 supplementation (150 and 350 mg/kg body weight) and assessed for any reduction in weight gain. Plasma leptin, insulin, adiponectin, and ghrelin of all groups were determined. H-1 NMR and LCMS methods were employed for phytochemical profiling of MLE60. Results: The supplementation of MLE60 did not affect food intake indicating that appetite suppression might not be the main anti-obesity mechanism involved. In the treated groups, MLE60 prevented weight gain, most likely through an inhibition of pancreatic and lipoprotein activity with a positive influence on the lipid profiles and a reduction in LDL levels. MLE60 also attenuated visceral fat deposition in treated subjects with improvement in the plasma levels of obesity-linked factors. (1)Spectral analysis showed the presence of several bioactive compounds with rutin being more predominant. Conclusion: MLE60 shows promise as an anti-obesity agents and warrants further research.
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页数:13
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