Determination of ibuprofen enantiomers in human plasma by HPLC-MS/MS: validation and application in neonates

被引：20

作者：

Chen, Tingting ^{[1
]}

Li, Qin ^{[1
]}

Lu, Jinmiao ^{[1
]}

Yu, Chen ^{[2
]}

Chen, Chao ^{[3
]}

Li, Zhiping ^{[1
]}

机构：

[1] Fudan Univ, Childrens Hosp, Dept Pharm, 399 Wanyuan Rd, Shanghai 201102, Peoples R China

[2] Shanghai Xuhui Cent Hosp, Cent Lab, Shanghai, Peoples R China

[3] Fudan Univ, Childrens Hosp, Dept Neonatol, Shanghai 201102, Peoples R China

来源：

BIOANALYSIS | 2016年 / 8卷 / 12期

关键词：

enantiomers; HPLC-MS/MS; ibuprofen; interference; neonate; PERFORMANCE LIQUID-CHROMATOGRAPHY; RESOLUTION MASS-SPECTROMETRY; ENANTIOSELECTIVE DETERMINATION; PREMATURE-INFANTS; CHIRAL INVERSION; PRETERM INFANTS; PHARMACOKINETICS; DERIVATIZATION; SERUM;

D O I：

10.4155/bio-2016-0013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Aim: An adaptive method to determine ibuprofen enantiomers with limited volume of plasma required is necessary for investigating PK of ibuprofen in neonates. Results: Enantiomer separation was achieved on a Lux cellulose 3 column with mobile phase consisting of methanol water (85: 15, v/v) and formic acid (0.0075%) at isocratic rate of 0.2 ml/min. Calibration curve is linear for each enantiomer at the range of 0.1-60 mu g/ml. Validation was conducted and results met requirements regarding to intra-and inter-run precision, accuracy and recovery. No matrix effect or interference was observed from neonatal plasma or comedications. Only 20 mu l of plasma was requested in this study. Conclusion: This assay was specific and reliable to quantify ibuprofen enantiomers in neonate plasma.

引用

页码：1237 / 1250

页数：14

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