The influence of crosslinking amylose-methacrylic acid graft copolymers on the release of BSA

被引：1
|
作者：
Silva, Itziar [1 ]
Gurruchaga, Marilo [1 ]
Goni, Isabel [1 ]
机构：
[1] Univ Basque Country, Inst Polymer Mat, POLYMAt, Dept Polymer Sci & Technol, P Code 1072, San Sebastian 20080, Spain
来源：
MACROMOLECULAR SYMPOSIA | 2007年 / 253卷
关键词：
crosslinking; drug delivery systems; graft copolymers; proteins; starch;
D O I：
10.1002/masy.200750711
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
One of the biggest challenges in the drug delivery field is to obtain oral systems for the release of pepticles and proteins, enabling their use as therapeutic agents for clinical applications. The aim of this work is to obtain biodegradable copolymers suitable for the development of matrices which offer controlled release of proteins to be administered orally. Graft copolymers of amylose-methacrylic acid were synthesized using different amounts of the crosslinker N, N'-methylenediacrylamide. The influence on the release profiles of bovine serum albumin (BSA) was researched.
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页码：82 / 87
页数：6
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