RSK2: a promising therapeutic target for the treatment of triple-negative breast cancer

被引:15
作者
My-my Huynh [1 ]
Jayanthan, Aarthi [1 ]
Pambid, Mary Rose [1 ]
Los, Gerrit [2 ]
Dunn, Sandra E. [1 ,2 ]
机构
[1] Phoenix Mol Designs, 887 Great Northern Way, Vancouver, BC V5T 4T5, Canada
[2] Phoenix Mol Designs, San Diego, CA USA
关键词
Kinase inhibitors; RSK2; targeted therapy; triple-negative breast cancer (TNBC); INHIBITORS; POTENT; CELLS;
D O I
10.1080/14728222.2020.1709824
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:1 / 5
页数:5
相关论文
共 15 条
[1]   Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers [J].
Aronchik, Ida ;
Appleton, Brent A. ;
Basham, Stephen E. ;
Crawford, Kenneth ;
Del Rosario, Mercedita ;
Doyle, Laura V. ;
Estacio, William F. ;
Lan, Jiong ;
Lindvall, Mika K. ;
Luu, Catherine A. ;
Ornelas, Elizabeth ;
Venetsanakos, Eleni ;
Shafer, Cynthia M. ;
Jefferson, Anne B. .
MOLECULAR CANCER RESEARCH, 2014, 12 (05) :803-812
[2]   Functional Viability Profiles of Breast Cancer [J].
Brough, Rachel ;
Frankum, Jessica R. ;
Sims, David ;
Mackay, Alan ;
Mendes-Pereira, Ana M. ;
Bajrami, Ilirjana ;
Costa-Cabral, Sara ;
Rafiq, Rumana ;
Ahmad, Amar S. ;
Cerone, Maria Antonietta ;
Natrajan, Rachael ;
Sharpe, Rachel ;
Shiu, Kai-Keen ;
Wetterskog, Daniel ;
Dedes, Konstantine J. ;
Lambros, Maryou B. ;
Rawjee, Teeara ;
Linardopoulos, Spiros ;
Reis-Filho, Jorge S. ;
Turner, Nicholas C. ;
Lord, Christopher J. ;
Ashworth, Alan .
CANCER DISCOVERY, 2011, 1 (03) :260-273
[3]   The RSK factors of activating the Ras/MAPK signaling cascade [J].
Carriere, Audrey ;
Ray, Hind ;
Blenis, John ;
Roux, Philippe P. .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2008, 13 :4258-4275
[4]   YB-1 Transforms Human Mammary Epithelial Cells Through Chromatin Remodeling Leading to the Development of Basal-Like Breast Cancer [J].
Davies, Alastair H. ;
Reipas, Kristen M. ;
Pambid, Mary Rose ;
Berns, Rachel ;
Stratford, Anna L. ;
Fotovati, Abbas ;
Firmino, Natalie ;
Astanehe, Arezoo ;
Hu, Kaiji ;
Maxwell, Christopher ;
Mills, Gordon B. ;
Dunn, Sandra E. .
STEM CELLS, 2014, 32 (06) :1437-1450
[5]  
Dunn S.E., 2017, [No title captured], Patent No. [WO2017141116A1, 2017141116, 2017141116A1]
[6]   In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models [J].
Hoeflich, Klaus P. ;
O'Brien, Carol ;
Boyd, Zachary ;
Cavet, Guy ;
Guerrero, Steve ;
Jung, Kenneth ;
Januario, Tom ;
Savage, Heidi ;
Punnoose, Elizabeth ;
Truong, Tom ;
Zhou, Wei ;
Berry, Leanne ;
Murray, Lesley ;
Amler, Lukas ;
Belvin, Marcia ;
Friedman, Lori S. ;
Lackner, Mark R. .
CLINICAL CANCER RESEARCH, 2009, 15 (14) :4649-4664
[7]   Discovery of Potent and Selective RSK Inhibitors as Biological Probes [J].
Jain, Rama ;
Mathur, Michelle ;
Lan, Jiong ;
Costales, Abran ;
Atallah, Gordana ;
Ramurthy, Savithri ;
Subramanian, Sharadha ;
Setti, Lina ;
Feucht, Paul ;
Warne, Bob ;
Doyle, Laura ;
Basham, Stephen ;
Jefferson, Anne B. ;
Lindvall, Mika ;
Appleton, Brent A. ;
Shafer, Cynthia M. .
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (17) :6766-6783
[8]   Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer [J].
Ludwik, Katarzyna A. ;
Campbell, J. Preston ;
Li, Mingzong ;
Li, Yu ;
Sandusky, Zachary M. ;
Pasic, Lejla ;
Sowder, Miranda E. ;
Brenin, David R. ;
Pietenpol, Jennifer A. ;
O'Doherty, George A. ;
Lannigan, Deborah A. .
MOLECULAR CANCER THERAPEUTICS, 2016, 15 (11) :2598-2608
[9]   Ribosomal S6 kinase (RSK) modulators: a patent review [J].
Ludwik, Katarzyna A. ;
Lannigan, Deborah A. .
EXPERT OPINION ON THERAPEUTIC PATENTS, 2016, 26 (09) :1061-1078
[10]   Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer [J].
Risom, Tyler ;
Langer, Ellen M. ;
Chapman, Margaret P. ;
Rantala, Juha ;
Fields, Andrew J. ;
Boniface, Christopher ;
Alvarez, Mariano J. ;
Kendsersky, Nicholas D. ;
Pelz, Carl R. ;
Johnson-Camacho, Katherine ;
Dobrolecki, Lacey E. ;
Chin, Koei ;
Aswani, Anil J. ;
Wang, Nicholas J. ;
Califano, Andrea ;
Lewis, Michael T. ;
Tomlin, Claire J. ;
Spellman, Paul T. ;
Adey, Andrew ;
Gray, Joe W. ;
Sears, Rosalie C. .
NATURE COMMUNICATIONS, 2018, 9