Concise total synthesis of cruentaren A

被引：59
作者：
Fuerstner, Alois [1 ]
Bindl, Martin [1 ]
Jean, Ludovic [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim An Der Ruhr, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 48期
关键词：
alkynes; macrolides; metathesis; natural products; protecting groups;
D O I：
10.1002/anie.200703839
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Converging on the target: The highly cytotoxic F-ATPase inhibitor cruentaren A constitutes an interesting lead in the quest for innovative chemotherapeutic agents for the treatment of various diseases, including cancer. Its synthesis was achieved in an overall yield of 3% by an expeditious convergent route involving a ring-closing aikyne metathesis reaction (RCAM) for the formation of the macrocyclic ring (see picture). (Chemical Equation Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：9275 / 9278
页数：4
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