Associated Malignancies in Patients with Waldenstrom's Macroglobulinemia and Their Kin

被引：31

作者：

Hanzis, Christina ^{[1
]}

Ojha, Rohit P. ^{[1
]}

Hunter, Zachary ^{[1
]}

Manning, Robert ^{[1
]}

Lewicki, Megan ^{[1
]}

Brodsky, Philip ^{[1
]}

Ioakimidis, Leukothea ^{[1
]}

Tripsas, Christina ^{[1
]}

Patterson, Christopher J. ^{[1
]}

Sheehy, Patricia ^{[1
]}

Treon, Steven P. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Bing Ctr Waldenstroms Macroglobulinemia, Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2011年 / 11卷 / 01期

关键词：

MONOCLONAL GAMMOPATHY; 1ST-DEGREE RELATIVES; MULTIPLE-MYELOMA; SOLID TUMORS; RISK; DELETIONS; NEOPLASMS; PATTERNS; 13Q14;

D O I：

10.3816/CLML.2011.n.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined the incidence of other malignancies in 924 Waldenstrom's Macroglobulinemia (WM) patients and their kin. A total of 225 (24.3%) patients had >= 1 additional malignancy, with 63% predating the WM diagnosis. The most common gender-adjusted malignancies were prostate (9.4%), breast (8.0%), non-melanoma skin (7.1%), hematologic (2.8%), melanoma (2.2%), lung (1.4%) and thyroid 1.1%). Among hematologic malignancies, all 13 cases of diffuse large B-cell lymphoma and 4 cases of acute myelogenous leukemia were diagnosed after WM, and were therapy-related. Familial WM subgroup analysis showed a higher incidence of prostate cancer (P = .046) in sporadic WM patients, while patients with familial WM had a higher incidence of lung cancer (P = .0043). An increased incidence of myeloid leukemias (P < .0001) was reported among kin of familial WM patients. These data reveal specific cancer associations with WM, and provide a basis for exploratory studies aimed at delineating a common genetic basis. Additionally, these studies suggest specific cancer clustering based on familial predisposition to WM.

引用

页码：88 / 92

页数：5

共 26 条

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