Review of Pharmaceutical Applications of N-Methyl-2-Pyrrolidone

被引：173
作者：
Jouyban, Abolghasem [1 ,2 ]
Fakhree, Mohammad A. A. [3 ]
Shayanfar, Ali [4 ]
机构：
[1] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran
[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 51664, Iran
[3] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz 51664, Iran
[4] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz 51664, Iran
来源：
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES | 2010年 / 13卷 / 04期
关键词：
N-METHYL-PYRROLIDONE; PLUS WATER MIXTURES; TRANSDERMAL DELIVERY; DEVELOPMENTAL TOXICITY; METHYLPYRROLIDONE NMP; OCCUPATIONAL-EXPOSURE; PENETRATION ENHANCERS; SKIN PERMEATION; 298.15; K; RATS;
D O I：
10.18433/J3P306
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
N-Methyl-2-pyrrolidone (NMP) is a very strong solubilizing agent that has important applications in different fields of industry. This review presents NMP's physicochemical characteristics, its applications - especially in the pharmaceutical sciences, pharmacokinetics and toxicity. The characteristics of NMP, such as physicochemical properties, solubilization efficacy, toxicity, and adverse effects, are compared with those of other common solvents used in pharmaceutical industries. This review shows that NMP is an acceptable pharmaceutical solvent and that its efficacy, toxicity, and side effects are comparable with those of other common solvents.
引用
收藏
页码：524 / 535
页数：12
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