Review of Pharmaceutical Applications of N-Methyl-2-Pyrrolidone

被引：166

作者：

Jouyban, Abolghasem ^{[1
,2
]}

Fakhree, Mohammad A. A. ^{[3
]}

Shayanfar, Ali ^{[4
]}

机构：

[1] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 51664, Iran

[3] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz 51664, Iran

[4] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz 51664, Iran

来源：

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES | 2010年 / 13卷 / 04期

关键词：

N-METHYL-PYRROLIDONE; PLUS WATER MIXTURES; TRANSDERMAL DELIVERY; DEVELOPMENTAL TOXICITY; METHYLPYRROLIDONE NMP; OCCUPATIONAL-EXPOSURE; PENETRATION ENHANCERS; SKIN PERMEATION; 298.15; K; RATS;

D O I：

10.18433/J3P306

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

N-Methyl-2-pyrrolidone (NMP) is a very strong solubilizing agent that has important applications in different fields of industry. This review presents NMP's physicochemical characteristics, its applications - especially in the pharmaceutical sciences, pharmacokinetics and toxicity. The characteristics of NMP, such as physicochemical properties, solubilization efficacy, toxicity, and adverse effects, are compared with those of other common solvents used in pharmaceutical industries. This review shows that NMP is an acceptable pharmaceutical solvent and that its efficacy, toxicity, and side effects are comparable with those of other common solvents.

引用

页码：524 / 535

页数：12

共 80 条

[1] Experimental exposure of male volunteers to N-methyl-2-pyrrolidone (NMP): Acute effects and pharmacokinetics of NMP in plasma and urine
Akesson, B
Paulsson, K
[J]. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1997, 54 (04) : 236 - 240
[2] Akesson B, 1997, DRUG METAB DISPOS, V25, P267
[3] ABSORPTION THROUGH HUMAN-SKIN OF IBUPROFEN AND FLURBIPROFEN - EFFECT OF DOSE VARIATION, DEPOSITED DRUG FILMS, OCCLUSION AND THE PENETRATION ENHANCER N-METHYL-2-PYRROLIDONE
AKHTER, SA
BARRY, BW
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1985, 37 (01) : 27 - 37
[4] [Anonymous], 2009, British Pharmacopoeia
[5] [Anonymous], 2008, US PHARM NAT FORM US
[6] Solubility of sparingly-soluble ionizable drugs
Avdeef, Alex
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (07) : 568 - 590
[7] Effect of penetration enhancers on the transdermal delivery of bupranolol through rat skin
Babu, RJ
Pandit, JK
[J]. DRUG DELIVERY, 2005, 12 (03) : 165 - 169
[8] Exploring the potential of N-methyl pyrrolidone as a cosurfactant in the microemulsion systems
Bachhav, Y. G.
Date, A. A.
Patravale, V. B.
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 326 (1-2) : 186 - 189
[9] Ambient monitoring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility
Bader, M
Rosenberger, W
Rebe, T
Keener, SA
Brock, TH
Hemmerling, HJ
Wrbitzky, R
[J]. INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 2006, 79 (05) : 357 - 364
[10] Human volunteer study on the inhalational and dermal absorption of N-methyl-2-pyrrolidone (NMP) from the vapour phase
Bader, Michael
Wrbitzky, Renate
Blaszkewicz, Meinolf
Schaeper, Michael
van Thriel, Christoph
[J]. ARCHIVES OF TOXICOLOGY, 2008, 82 (01) : 13 - 20

← 1 2 3 4 5 6 7 8 →