Survival of the fittest: metabolic adaptations in cancer

被引：18

作者：

Berardi, Marcelo J. ^{[2
]}

Fantin, Valeria R. ^{[1
]}

机构：

[1] Agios Pharmaceut, Cambridge, MA 02139 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2011年 / 21卷 / 01期

关键词：

RENAL-CELL CANCER; C-MYC; AEROBIC GLYCOLYSIS; PROLIFERATING CELLS; GLUCOSE-METABOLISM; OXIDATIVE STRESS; PYRUVATE-KINASE; ACHILLES-HEEL; GROWTH-FACTOR; MUTATIONS;

D O I：

10.1016/j.gde.2010.10.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Malignant transformation is often a multistep process characterized by an initial period of avascular growth. Rapid cell proliferation creates areas within the emerging preneoplastic lesion with limited diffusion of oxygen and nutrients. In this context, activation of oncogenes, loss of tumor suppressors as well as additional adaptive mechanisms drive a profound metabolic rewiring to overcome the environmental constraints. The emerging cells are in principle better suited to proliferate and survive in the hostile tumor microenvironment. Furthermore, some of the acquired metabolic traits impact their metastatic behavior and response to therapy. It is becoming increasingly clear that malignant cells are highly dependent on certain nutrients, an Achilles' heel of cancer and an opportunity for therapeutic intervention.

引用

页码：59 / 66

页数：8

共 67 条

[1]

ABOUKHALIL WH, 1983, CANCER RES, V43, P1990

[2] Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma [J].

Baysal, BE ;

Ferrell, RE ;

Willett-Brozick, JE ;

Lawrence, EC ;

Myssiorek, D ;

Bosch, A ;

van der Mey, A ;

Taschner, PEM ;

Rubinstein, WS ;

Myers, EN ;

Richard, CW ;

Cornelisse, CJ ;

Devilee, P ;

Devlin, B .

SCIENCE, 2000, 287 (5454) :848-851

[3] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [J].

Bensaad, Karim ;

Tsuruta, Atsushi ;

Selak, Mary A. ;

Calvo Vidal, M. Nieves ;

Nakano, Katsunori ;

Bartrons, Ramon ;

Gottlieb, Eyal ;

Vousden, Karen H. .

CELL, 2006, 126 (01) :107-120

[4] Aerobic glycolysis by proliferating cells: Protection against oxidative stress at the expense of energy yield [J].

Brand, K .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1997, 29 (04) :355-364

[5] Aerobic glycolysis by proliferating cells: A protective strategy against reactive oxygen species [J].

Brand, KA ;

Hermfisse, U .

FASEB JOURNAL, 1997, 11 (05) :388-395

[6] Mitochondrial mutations in cancer [J].

Brandon, M. ;

Baldi, P. ;

Wallace, D. C. .

ONCOGENE, 2006, 25 (34) :4647-4662

[7]

CHEN LB, 1988, ANNU REV CELL BIOL, V4, P155, DOI 10.1146/annurev.cellbio.4.1.155

[8] Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer [J].

Chiche, Johanna ;

Brahimi-Horn, M. Christiane ;

Pouyssegur, Jacques .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2010, 14 (04) :771-794

[9] The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth [J].

Christofk, Heather R. ;

Vander Heiden, Matthew G. ;

Harris, Marian H. ;

Ramanathan, Arvind ;

Gerszten, Robert E. ;

Wei, Ru ;

Fleming, Mark D. ;

Schreiber, Stuart L. ;

Cantley, Lewis C. .

NATURE, 2008, 452 (7184) :230-U74

[10] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate [J].

Dang, Lenny ;

White, David W. ;

Gross, Stefan ;

Bennett, Bryson D. ;

Bittinger, Mark A. ;

Driggers, Edward M. ;

Fantin, Valeria R. ;

Jang, Hyun Gyung ;

Jin, Shengfang ;

Keenan, Marie C. ;

Marks, Kevin M. ;

Prins, Robert M. ;

Ward, Patrick S. ;

Yen, Katharine E. ;

Liau, Linda M. ;

Rabinowitz, Joshua D. ;

Cantley, Lewis C. ;

Thompson, Craig B. ;

Heiden, Matthew G. Vander ;

Su, Shinsan M. .

NATURE, 2009, 462 (7274) :739-U52

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